2. Gene
  3. MVD - mevalonate diphosphate decarboxylase Gene

MVD - mevalonate diphosphate decarboxylase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MPD; MDDase; POROK7; FP17780

Gene ID: 4597 | Gene type: protein coding

About MVD

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:88,651,940-88,663,091 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 12.6), duodenum (RPKM 12.3) and 25 other tissues.

Summary

The Enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in Cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

MVD Products(1)

mRNA Protein Name
NM_002461.3 NP_002452.1 diphosphomevalonate decarboxylase

MVD Protein Structure

GHMP_kinases_N

GHMP_kinases_N: GHMP kinases N terminal domain (112 - 156)

  • 0
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  • 400 a.a.
Protein Preferred Names Protein Names

diphosphomevalonate decarboxylase

mevalonate (diphospho) decarboxylase

Related Diseases

Diseases Alias
Porokeratosis 7, Multiple Types

POROK7

Porokeratosis 7, Disseminated Superficial Actinic Type
Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1
Linear Porokeratosis

Congenital Facial Linear Porokeratosis

Porokeratosis, Linear
Scirrhous Adenocarcinoma

Adenocarcinoma, Scirrhous

Adenocarcinoma With Productive Fibrosis
Punctate Porokeratosis

Porokeratosis, Punctate

Keratoderma, Palmoplantar, Punctate Type Ii
Ck Syndrome

CKS

X-Linked Intellectual Disability-Microcephaly-Cortical Malformation-Thin Habitus Syndrome

Mental Retardation, X-Linked, With Thin Body Habitus And Cortical Malformation
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1596 Gluten Exorphin C Inhibitor 98.97% Unkown
HY-P3632 [DAla2, DArg6] Dynorphin A, (1-13) (porcine) / Unkown
HY-RS08856 MVD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MVD VGNC VGNC:31767
Canis familiaris MVD VGNC VGNC:43508
Felis catus MVD VGNC VGNC:68364
Rattus norvegicus MVD RGD RGD:621292
Mus musculus MVD MGD MGI:2179327
Macaca mulatta MVD VGNC VGNC:82192