NEO1 - neogenin 1 Gene

Homo sapiens

Also known as NGN; IGDCC2; NTN1R2

Gene ID: 4756 | Gene type: protein coding

About NEO1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,051,692-73,305,206 (from NCBI)

This gene has 11 transcripts (splice variants), 244 orthologues and 36 paralogues. Broad expression in colon (RPKM 23.2), skin (RPKM 16.0) and 23 other tissues.

Summary

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

NEO1 Products(3)

mRNA	Protein	Name
NM_001172623.1	NP_001166094.1	neogenin isoform 2 precursor
NM_001172624.1	NP_001166095.1	neogenin isoform 3 precursor
NM_002499.4	NP_002490.2	neogenin isoform 1 precursor

NEO1 Protein Structure

Ig_2

I-set

fn3

Neogenin_C

0
300
600
900
1200
1461 a.a.

Protein Preferred Names

Protein Names

neogenin

immunoglobulin superfamily DCC subclass member 2

Recombinant NEO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79339	Neogenin Protein, Human (HEK293, His)	Q92859 (A34-M1104)	≥95%
HY-P701081	Neogenin Protein, Human (HEK293, hFc)	Q92859-1 (A34-L1105)	≥95%

Related Diseases

Diseases

Alias

Corneal Intraepithelial Neoplasm

Hemochromatosis Type 2

Juvenile Hemochromatosis	Juvenile Hereditary Hemochromatosis
Hfe2	Jhh
Hemochromatosis Juvenile	Iron Overload Disease Juvenile
Hemochromatosis, Juvenile	Hemochromatosis, Type 2
Hemochromatosis	Hemochromatosis, Type 1

Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH	Bone Dysplasia With Medullary Fibrosarcoma
Bdmf	Bone Dysplasia With Malignant Fibrous Histiocytoma
Hardcastle Syndrome	Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome
Myopathy, Limb-Girdle, With Bone Fragility	Bone Dysplasia-Medullary Fibrosarcoma Syndrome
Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome	Dms-Mfh
Limb-Girdle Myopathy With Bone Fragility	Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1

Dysequilibrium Syndrome	CAMRQ1
Des	Cerebellar Ataxia, Intellectual Disability, And Dysequilibrium Syndrome 1
Cerebellar Hypoplasia, Vldlr-Associated	Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1
Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome	Uner Tan Syndrome
Vldlr Cerebellar Hypoplasia	Vldlrch
Vldlr-Associated Cerebellar Hypoplasia	Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 1
Cerebellar Ataxia, Congenital, And Mental Retardation, Autosomal Recessive	Camrq
Cerebellar Ataxia, Mental Retardation, Dysequilibrium Syndrome 1	Cerebellar Disorder, Nonprogressive, With Intellectual Disability
Cerebellar Hypoplasia, Vldlr Associated	Autosomal Recessive Cerebellar Ataxia With Mental Retardation
Autosomal Recessive Cerebellar Hypoplasia With Cerebral Gyral Simplification	Cerebellar Disorder, Nonprogressive, With Mental Retardation
Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion	Chmrq1
Des-Vldlr	Dysequilibrium Syndrome-Vldlr
Vldlr-Ch	Camrq Syndrome
Cerebellar Ataxia-Intellectual Disability-Dysequilibrium Syndrome Syndrome	Non-Progressive Cerebellar Ataxia-Intellectual Disability Syndrome
Uts	Cerebellar Hypoplasia Vldlr-Associated
Dialysis Disequilibrium Syndrome

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09209	NEO1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NEO1	VGNC	VGNC:32007
Rattus norvegicus	NEO1	RGD	RGD:619837
Felis catus	NEO1	VGNC	VGNC:80901
Macaca mulatta	NEO1	VGNC	VGNC:75314
Mus musculus	NEO1	MGD	MGI:1097159
Canis familiaris	NEO1	VGNC	VGNC:43745
Others	NEO1	NCBI