CNOT4 - CCR4-NOT transcription complex subunit 4 Gene

Homo sapiens

Also known as NOT4; NOT4H; CLONE243

Gene ID: 4850 | Gene type: protein coding

About CNOT4

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,361,795-135,510,102 (from NCBI)

This gene has 11 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

CNOT4 Products(12)

mRNA	Protein	Name
NM_001008225.3	NP_001008226.1	CCR4-NOT transcription complex subunit 4 isoform b
NM_001190847.2	NP_001177776.1	CCR4-NOT transcription complex subunit 4 isoform c
NM_001190848.2	NP_001177777.1	CCR4-NOT transcription complex subunit 4 isoform d
NM_001190849.2	NP_001177778.1	CCR4-NOT transcription complex subunit 4 isoform e
NM_001190850.2	NP_001177779.1	CCR4-NOT transcription complex subunit 4 isoform f
NM_001393370.1	NP_001380299.1	CCR4-NOT transcription complex subunit 4 isoform f
NM_001393371.1	NP_001380300.1	CCR4-NOT transcription complex subunit 4 isoform g
NM_001393372.1	NP_001380301.1	CCR4-NOT transcription complex subunit 4 isoform h
NM_001393373.1	NP_001380302.1	CCR4-NOT transcription complex subunit 4 isoform i
NM_001393374.1	NP_001380303.1	CCR4-NOT transcription complex subunit 4 isoform a
NM_001393375.1	NP_001380304.1	CCR4-NOT transcription complex subunit 4 isoform k
NM_013316.4	NP_037448.2	CCR4-NOT transcription complex subunit 4 isoform a

CNOT4 Protein Structure

zf-RING_4

RRM_5

0
100
200
300
400
500
575 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 4

CCR4-associated factor 4

Related Diseases

Diseases

Alias

Adenoiditis

Chronic Adenoiditis

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Microphthalmia, Syndromic 1

MCOPS1	Lenz Microphthalmia Syndrome
Lenz Dysplasia	Mcops4
Syndromic Microphthalmia 1	Lenz Microphthalmia
Maa	Microphthalmia Or Anophthalmos With Associated Anomalies
Syndromic Microphthalmia Type 4	Microphthalmia, Syndromic 4
Microphthalmia, Syndromic 4, Formerly	Mcops4, Formerly
Anop1, Formerly	Maa, Formerly
Lenz Type Microphthalmia	Syndromic Microphthalmia 4
Microphthalmia Lenz Type	Microphthalmia Syndromic 1
Syndromic Microphthalmia Type 1	Microphthalmia Syndromic 4
Microphthalmia With Ankyloblepharon And Intellectual Disability	Microphthalmia, Lenz Type
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome	Microphthalmia, Syndromic, 1
Anop1	Microphthalmia, Syndromic, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02904	CNOT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CNOT4	RGD	RGD:1310318
Mus musculus	CNOT4	MGD	MGI:1859026
Canis familiaris	CNOT4	VGNC	VGNC:39415
Macaca mulatta	CNOT4	VGNC	VGNC:71389
Felis catus	CNOT4	VGNC	VGNC:68518
Bos taurus	CNOT4	VGNC	VGNC:27519

Name
Email *

	Sorry, but the email address you supplied was invalid.