Nod1 - nucleotide-binding oligomerization domain containing 1 Gene

Rattus norvegicus

Also known as RGD1562269

Gene ID: 500133 | Gene type: protein coding

About Nod1

Primary_assembly 4: 84,060,880-84,111,404 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 201 orthologues, 21 paralogues and is associated with 11 phenotypes. Biased expression in Lung (RPKM 116.8), Spleen (RPKM 113.4) and 9 other tissues.

Summary

Predicted to enable CARD domain binding activity; pattern recognition receptor activity; and protein homodimerization activity. Involved in positive regulation of cell death; positive regulation of cytokine production; and positive regulation of nitric-oxide synthase activity. Predicted to be located in basolateral plasma membrane; cytosol; and phagocytic vesicle. Predicted to be anchored component of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nod1 Products(1)

mRNA	Protein	Name
NM_001109236.1	NP_001102706.1	nucleotide-binding oligomerization domain-containing protein 1

Protein Preferred Names

Protein Names

nucleotide-binding oligomerization domain-containing protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.56%	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nod1	NCBI	NCBI:10392

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