2. Gene
  3. NOX3 - NADPH oxidase 3 Gene

NOX3 - NADPH oxidase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MOX-2; GP91-3

Gene ID: 50508 | Gene type: protein coding

About NOX3

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:155,395,368-155,455,839 (from NCBI)

This gene has 1 transcript (splice variant), 136 orthologues and 6 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other Reactive Oxygen Species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]

NOX3 Products(1)

mRNA Protein Name
NM_015718.3 NP_056533.1 NADPH oxidase 3

NOX3 Protein Structure

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (58 - 217)

FAD_binding_8

FAD_binding_8: FAD-binding domain (293 - 391)

NAD_binding_6

NAD_binding_6: Ferric reductase NAD binding domain (401 - 548)

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  • 568 a.a.
Protein Preferred Names Protein Names

NADPH oxidase 3

NADPH oxidase catalytic subunit-like 3

Related Diseases

Diseases Alias
Drug-Induced Hearing Loss

Drug Induced Hearing Loss
Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction
Granulomatous Disease, Chronic, X-Linked

CGDX

Chronic Granulomatous Disease, X-Linked

X-Linked Chronic Granulomatous Disease

Cgd

Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked

Cdgx

X-Linked Chronic Cytochrome B-Negative Granulomatous Disease

Chronic Granulomatous Disease Cytochrome B-Negative X-Linked

Chronic Granulomatous Disease Cytochrome B-Positive X-Linked

Granulomatous Disease, Chronic, X-Linked, Variant
Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-120801 APX-115 Inhibitor 99.58% Phase 2
HY-120801A APX-115 free base Inhibitor 98.11% Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126195 Fluoflavine Inhibitor 99.41% Unkown
HY-RS09460 NOX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NOX3 VGNC VGNC:43904
Felis catus NOX3 VGNC VGNC:68523
Mus musculus NOX3 MGD MGI:2681162
Rattus norvegicus NOX3 RGD RGD:1303190
Macaca mulatta NOX3 VGNC VGNC:75375
Bos taurus NOX3 VGNC VGNC:32183