2. Gene
  3. Pten - phosphatase and tensin homolog Gene

Pten - phosphatase and tensin homolog Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Mmac; TEP1; MMAC1

Gene ID: 50557 | Gene type: protein coding

About Pten

Primary_assembly 1: 230,630,338-230,696,838 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 150 orthologues, 5 paralogues and is associated with 162 phenotypes. Biased expression in Adrenal (RPKM 635.2), Lung (RPKM 588.6) and 9 other tissues.

Summary

Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; dephosphorylation; and negative regulation of transport. Located in several cellular components, including dendritic spine; mitochondrion; and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; fatty liver disease; glucose metabolism disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast Cancer (multiple); gastrointestinal system Cancer (multiple); nervous system Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human PTEN (Phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Apr 2022]

Pten Products(1)

mRNA Protein Name
NM_031606.2 NP_113794.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Pten Protein Structure

PTP_PTEN

PTP_PTEN: cd14509 (23 - 180)

PTEN_C2

PTEN_C2: pfam10409 (187 - 348)

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  • 403 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

mutated in multiple advanced cancers 1

phosphatase and tensin homolog deleted on chromosome ten

protein tyrosine phosphatase and tensin-like protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13074 VO-Ohpic trihydrate Inhibitor ≥98.0% Unkown
HY-15842 SF1670 Inhibitor ≥98.0% Unkown
HY-128693 BpV(HOpic) Inhibitor ≥98.0% Unkown
HY-N1435 Oroxin B Activator 99.71% Unkown
HY-N1441 Afzelin 99.62% Unkown
HY-122818 bpV(phen) trihydrate Inhibitor ≥98.0% Unkown
HY-N2116 Ginkgolic acid C17:1 Inhibitor 99.90% Unkown
HY-160093 SQLE-IN-1 Inducer 98.82% Unkown
HY-136065 bpV(phen) Inhibitor / Unkown
HY-110067 VO-OHPic Inhibitor / Unkown
HY-N8884 Coelonin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pten NCBI NCBI:5728