2. Gene
  3. CKLF - chemokine like factor Gene

CKLF - chemokine like factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C32; CKLF1; CKLF2; CKLF3; CKLF4; UCK-1; HSPC224

Gene ID: 51192 | Gene type: protein coding

About CKLF

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:66,552,563-66,566,287 (from NCBI)

This gene has 8 transcripts (splice variants), 147 orthologues and 14 paralogues. Ubiquitous expression in appendix (RPKM 18.6), testis (RPKM 17.1) and 24 other tissues.

Summary

The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]

CKLF Products(5)

mRNA Protein Name
NM_001040138.3 NP_001035228.1 chemokine-like factor isoform e
NM_016326.3 NP_057410.1 chemokine-like factor isoform c
NM_016951.4 NP_058647.1 chemokine-like factor isoform a
NM_181640.2 NP_857591.1 chemokine-like factor isoform b
NM_181641.2 NP_857592.1 chemokine-like factor isoform d
Protein Preferred Names Protein Names

chemokine-like factor

chemokine-like factor 1

Related Diseases

Diseases Alias
Brugada Syndrome 2

BRGDA2

Brugada Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3982 CKLF1-C19 Chemical 99.95% Unkown
HY-P3418 CKLF1-C27 98.50% Unkown
HY-P3418A CKLF1-C27 TFA / Unkown
HY-RS02737 CKLF Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CKLF MGD MGI:1922708
Canis familiaris CKLF VGNC VGNC:39290
Rattus norvegicus CKLF RGD RGD:620708