2. Gene
  3. HACD3 - 3-hydroxyacyl-CoA dehydratase 3 Gene

HACD3 - 3-hydroxyacyl-CoA dehydratase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BIND1; B-IND1; HSPC121; PTPLAD1

Gene ID: 51495 | Gene type: protein coding

About HACD3

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,530,463-65,578,349 (from NCBI)

This gene has 12 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 49.9), adrenal (RPKM 46.4) and 25 other tissues.

Summary

Enables 3-hydroxyacyl-CoA dehydratase activity and Enzyme binding activity. Involved in fatty acid biosynthetic process; positive regulation by virus of viral protein levels in host cell; and positive regulation of viral genome replication. Located in endoplasmic reticulum and nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]

HACD3 Products(2)

mRNA Protein Name
NM_001411136.1 NP_001398065.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform 2
NM_016395.4 NP_057479.2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform 1

HACD3 Protein Structure

CS

CS: CS domain (9 - 84)

PTPLA

PTPLA: Protein tyrosine phosphatase-like protein, PTPLA (195 - 357)

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  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

butyrate-induced protein 1

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 34

Erythrokeratodermia With Ataxia

Spinocerebellar Ataxia Type 34

SCA34

Erythrokeratodermia - Ataxia

Giroux Barbeau Syndrome

Spinocerebellar Ataxia And Erythrokeratodermia

Erythrokeratodermia Ataxia
Fiedler'S Myocarditis

Isolated Myocarditis

Fiedler Myocarditis

Idiopathic Myocarditis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05986 HACD3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HACD3 VGNC VGNC:73225
Felis catus HACD3 VGNC VGNC:62746
Bos taurus HACD3 VGNC VGNC:29738
Canis familiaris HACD3 VGNC VGNC:54310
Mus musculus HACD3 MGD MGI:1889341
Rattus norvegicus HACD3 RGD RGD:1565496