PGK2 - phosphoglycerate kinase 2 Gene

Homo sapiens

Also known as PGKB; PGKPS; HEL-S-272; dJ417L20.2

Gene ID: 5232 | Gene type: protein coding

About PGK2

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:49,785,660-49,787,285 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 1 paralogue.

Summary

This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

PGK2 Products(1)

mRNA	Protein	Name
NM_138733.5	NP_620061.2	phosphoglycerate kinase 2

PGK2 Protein Structure

PGK

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

phosphoglycerate kinase 2

epididymis secretory protein Li 272

Recombinant PGK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75972	PGK2 Protein, Human (sf9, His)	P07205 (S2-M417)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 58

IMD58	Severe Combined Immunodeficiency Due To Carmil2 Deficiency
Combined Immunodeficiency Due To Carmil2 Deficiency	Combined Immunodeficiency Due To Rltpr Deficiency

Phosphoglycerate Kinase 1 Deficiency

Pgk1 Deficiency	Glycogen Storage Disease Due To Phosphoglycerate Kinase 1 Deficiency
Phosphoglycerate Kinase Deficiency	Pgk Deficiency
Glycogenosis Due To Phosphoglycerate Kinase 1 Deficiency	Gsd Due To Phosphoglycerate Kinase 1 Deficiency
Deficiency Of Phosphoglycerate Kinase	PGK1D
Deficiency, Phosphoglycerate Kinase 1

Testicular Torsion

Spermatic Cord Torsion	Torsion Of Testis
Torsion Of Testicular Cord	Torsion Of Testicle
Torsion Of Spermatic Cord	Torsion Of Spermatic Cord Nos

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10385	PGK2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PGK2	VGNC	VGNC:75966
Felis catus	PGK2	VGNC	VGNC:68815
Mus musculus	PGK2	MGD	MGI:97563
Rattus norvegicus	PGK2	RGD	RGD:1306627
Others	PGK2	NCBI