POLRMT - RNA polymerase mitochondrial Gene

Homo sapiens

Also known as APOLMT; MTRNAP; MTRPOL; COXPD55; h-mtRPOL

Gene ID: 5442 | Gene type: protein coding

About POLRMT

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:617,221-633,537 (from NCBI)

This gene has 8 transcripts (splice variants), 198 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 15.0), kidney (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]

POLRMT Products(21)

mRNA	Protein	Name
NM_001407805.1	NP_001394734.1	DNA-directed RNA polymerase, mitochondrial isoform 1 precursor
NM_001407806.1	NP_001394735.1	DNA-directed RNA polymerase, mitochondrial isoform 2 precursor
NM_001407807.1	NP_001394736.1	DNA-directed RNA polymerase, mitochondrial isoform 3 precursor
NM_001407808.1	NP_001394737.1	DNA-directed RNA polymerase, mitochondrial isoform 4 precursor
NM_001407809.1	NP_001394738.1	DNA-directed RNA polymerase, mitochondrial isoform 6 precursor
NM_001407810.1	NP_001394739.1	DNA-directed RNA polymerase, mitochondrial isoform 7 precursor
NM_001407811.1	NP_001394740.1	DNA-directed RNA polymerase, mitochondrial isoform 8 precursor
NM_001407812.1	NP_001394741.1	DNA-directed RNA polymerase, mitochondrial isoform 9 precursor
NM_001407813.1	NP_001394742.1	DNA-directed RNA polymerase, mitochondrial isoform 10 precursor
NM_001407814.1	NP_001394743.1	DNA-directed RNA polymerase, mitochondrial isoform 11 precursor
NM_001407815.1	NP_001394744.1	DNA-directed RNA polymerase, mitochondrial isoform 12 precursor
NM_001407816.1	NP_001394745.1	DNA-directed RNA polymerase, mitochondrial isoform 13 precursor
NM_001407829.1	NP_001394758.1	DNA-directed RNA polymerase, mitochondrial isoform 14 precursor
NM_001407830.1	NP_001394759.1	DNA-directed RNA polymerase, mitochondrial isoform 15 precursor
NM_001407831.1	NP_001394760.1	DNA-directed RNA polymerase, mitochondrial isoform 16
NM_001407832.1	NP_001394761.1	DNA-directed RNA polymerase, mitochondrial isoform 17 precursor
NM_001407833.1	NP_001394762.1	DNA-directed RNA polymerase, mitochondrial isoform 18
NM_001407834.1	NP_001394763.1	DNA-directed RNA polymerase, mitochondrial isoform 19
NM_001407835.1	NP_001394764.1	DNA-directed RNA polymerase, mitochondrial isoform 20
NM_001407836.1	NP_001394765.1	DNA-directed RNA polymerase, mitochondrial isoform 21
NM_005035.4	NP_005026.3	DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

POLRMT Protein Structure

RPOL_N

RNA_pol

0
200
400
600
800
1000
1230 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerase, mitochondrial

polymerase (RNA) mitochondrial (DNA directed)

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 55

COXPD55

Cardiomyopathy, Infantile Hypertrophic

Infantile Hypertrophic Cardiomyopathy

CMHI

Mitochondrial Dna Depletion Syndrome 4a

Alpers Syndrome	Alpers-Huttenlocher Syndrome
Alpers Progressive Infantile Poliodystrophy	Alpers Diffuse Degeneration Of Cerebral Gray Matter With Hepatic Cirrhosis
Alpers Disease	Progressive Sclerosing Poliodystrophy
Pndc	Diffuse Cerebral Sclerosis Of Schilder
MTDPS4A	Neuronal Degeneration Of Childhood With Liver Disease, Progressive
Alper'S Syndrome	Alpers' Disease Or Gray-Matter Degeneration
Diffuse Cerebral Degeneration In Infancy	Infantile Poliodystrophy
Poliodystrophia Cerebri Progressiva	Progressive Cerebral Poliodystrophy
Alpers' Disease	Alpers Progressive Sclerosing Poliodystrophy
Progressive Neuronal Degeneration Of Childhood With Liver Disease	Ahs
Mitochondrial Dna Depletion Syndrome 4a Alpers Type	Neuronal Degeneration Of Childhood With Liver Disease Progressive

Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy	Leber Hereditary Optic Neuropathy
LHON	Leber'S Hereditary Optic Neuropathy
Leber Optic Atrophy, Susceptibility To	Leber'S Optic Atrophy
LOAM	Loas
Leber'S Disease	Leber'S Optic Neuropathy
Optic Atrophy, Hereditary, Leber	Lhon, Modifier Of
Optic Atrophy, Leber Type	Hereditary Optic Neuroretinopathy
Leber Hereditary Optic Atrophy	Loa
Optic Atrophy Leber Type	Leber Hereditary Optic Neuropathy, Modifier
Leber Hereditary Optic Neuropathy Susceptibility	Modifier Of Leber Hereditary Optic Neuropathy
Lebers Hereditary Optic Neuropathy	Leber Congenital Amaurosis

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134539	IMT1	Inhibitor	98.03%	Unkown
HY-137067	IMT1B	Inhibitor	99.36%	Unkown
HY-RS10863	POLRMT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	POLRMT	VGNC	VGNC:108252
Rattus norvegicus	POLRMT	RGD	RGD:1304599
Mus musculus	POLRMT	MGD	MGI:1915843
Felis catus	POLRMT	VGNC	VGNC:68956
Bos taurus	POLRMT	VGNC	VGNC:33154

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