2. Gene
  3. FBXO42 - F-box protein 42 Gene

FBXO42 - F-box protein 42 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as JFK; Fbx42

Gene ID: 54455 | Gene type: protein coding

About FBXO42

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,246,840-16,352,480 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 6.4), fat (RPKM 5.1) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

FBXO42 Products(1)

mRNA Protein Name
NM_018994.3 NP_061867.1 F-box only protein 42

FBXO42 Protein Structure

F-box-like

F-box-like: F-box-like (48 - 82)

Kelch_3

Kelch_3: Galactose oxidase, central domain (131 - 182)

Kelch_2

Kelch_2: Kelch motif (231 - 274)

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  • 717 a.a.
Protein Preferred Names Protein Names

F-box only protein 42

just one F-box and Kelch domain-containing protein

Related Diseases

Diseases Alias
Desmoid Disease, Hereditary

Fif

DESMD

Hereditary Desmoid Disease

Familial Infiltrative Fibromatosis

Fibromatosis, Familial Infiltrative

Fibromatosis, Aggressive
Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome

Pallidopyramidal Syndrome

Parkinson Disease 15, Autosomal Recessive

PARK15

Pkps

Pallido-Pyramidal Syndrome

Parkinson'S Disease 15

Autosomal Recessive Early-Onset Parkinson Disease 15

Autosomal Recessive Early-Onset Parkinson'S Disease 15

Pallido-Pyramidal Disease

Parkinson Disease 15

Parkinson Disease 15 Autosomal Recessive

Pps

Parkinson Disease, Type 15
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04808 FBXO42 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FBXO42 RGD RGD:1304787
Macaca mulatta FBXO42 VGNC VGNC:72597
Mus musculus FBXO42 MGD MGI:1924992
Bos taurus FBXO42 VGNC VGNC:28913
Felis catus FBXO42 VGNC VGNC:62194
Canis familiaris FBXO42 VGNC VGNC:40782