SGTB - small glutamine rich tetratricopeptide repeat co-chaperone beta Gene

Homo sapiens

Also known as SGT2

Gene ID: 54557 | Gene type: protein coding

About SGTB

This gene has 2 transcripts (splice variants), 213 orthologues and 18 paralogues. Broad expression in brain (RPKM 18.1), appendix (RPKM 4.3) and 19 other tissues.

Summary

Predicted to enable molecular adaptor activity. Predicted to be involved in positive regulation of chaperone-mediated protein folding; posttranslational protein targeting to endoplasmic reticulum membrane; and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SGTB Products(1)

mRNA	Protein	Name
NM_019072.3	NP_061945.1	small glutamine-rich tetratricopeptide repeat-containing protein beta

SGTB Protein Structure

TPR_11

TPR_1

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

small glutamine-rich tetratricopeptide repeat-containing protein beta

beta-SGT

Related Diseases

Diseases

Alias

Pituitary Adenoma 1, Multiple Types

Pituitary Adenoma Predisposition	PITA1
Isolated Familial Somatotropinoma	Fis
Ifs	Somatotrophinoma, Familial
Acromegaly Due To Pituitary Adenoma 1	Pagh1
Pituitary Adenoma 1	Somatotropinoma, Familial Isolated
Somatotropic Adenoma	Somatotropinoma
Pituitary Gigantism	Hypophyseal Gigantism
Infantile And Juvenile Forms Of Acromegaly	Acromegaly Due To Pituitary Adenoma
Familial Isolated Pituitary Adenoma	Familial Isolated Somatotropinomas
Familial Somatotrophinoma	Fipa
Pituitary Adenoma, Growth Hormone-Secreting, 1	Gigantism Pituitary
Pituitary Adenoma, Type 1, Multiple Types	Gigantism
Pituitary Adenoma, Familial Isolated	Multiple Gastrointestinal Atresias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12817	SGTB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SGTB	VGNC	VGNC:46108
Felis catus	SGTB	VGNC	VGNC:65087
Bos taurus	SGTB	VGNC	VGNC:34554
Macaca mulatta	SGTB	VGNC	VGNC:77296
Mus musculus	SGTB	MGD	MGI:2444615
Rattus norvegicus	SGTB	RGD	RGD:727976