INO80 - INO80 complex ATPase subunit Gene

Homo sapiens

Also known as INOC1; INO80A

Gene ID: 54617 | Gene type: protein coding

About INO80

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,978,880-41,116,280 (from NCBI)

This gene has 17 transcripts (splice variants), 201 orthologues, 30 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 5.6), testis (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

INO80 Products(1)

mRNA	Protein	Name
NM_017553.3	NP_060023.1	chromatin-remodeling ATPase INO80

INO80 Protein Structure

DBINO

SNF2_N

Helicase_C

0
300
600
900
1200
1556 a.a.

Protein Preferred Names

Protein Names

chromatin-remodeling ATPase INO80

DNA helicase INO80

Related Diseases

Diseases

Alias

Combined Cellular And Humoral Immune Defects With Granulomas

Combined Immunodeficiency With Skin Granulomas	CCHIDG
Cid Due To Rag 1/2 Deficiency	Combined Immunodeficiency Due To Rag 1/2 Deficiency
Combined Immunodeficiency With Granulomatosis	CHIDG
Immune Defects, Combined Cellular And Humoral With Granulomas

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Grange Syndrome

Arterial Occlusive Disease, Progressive, With Hypertension, Heart Defects, Bone Fragility, And Brachysyndactyly	Grange Occlusive Arterial Syndrome
GRNG	Progressive Arterial Occlusive Disease-Hypertension-Heart Defects-Bone Fragility-Brachysyndactyly Syndrome

Fibromuscular Dysplasia

Floating-Harbor Syndrome

FLHS	Fhs
Pelletier-Leisti Syndrome	Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes
Leisti-Hollander-Rimoin Syndrome

Immunodeficiency 43

Hypoproteinemia, Hypercatabolic	IMD43
Beta-2-Microglobulin Deficiency	B2m Deficiency
Hypercatabolic Hypoproteinemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS06821	INO80 Human Pre-designed siRNA Set A	/	Unkown
HY-RS06822	INO80D Human Pre-designed siRNA Set A	/	Unkown
HY-RS06823	INO80E Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INO80	VGNC	VGNC:30205
Rattus norvegicus	INO80	RGD	RGD:1310969
Macaca mulatta	INO80	VGNC	VGNC:84358
Mus musculus	INO80	MGD	MGI:1915392
Felis catus	INO80	VGNC	VGNC:62926
Canis familiaris	INO80	VGNC	VGNC:42024
Others	INO80	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.