2. Gene
  3. FBXL19 - F-box and leucine rich repeat protein 19 Gene

FBXL19 - F-box and leucine rich repeat protein 19 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Fbl19; CXXC11; JHDM1C

Gene ID: 54620 | Gene type: protein coding

About FBXL19

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,922,851-30,948,783 (from NCBI)

This gene has 8 transcripts (splice variants), 362 orthologues and 15 paralogues. Broad expression in testis (RPKM 9.4), brain (RPKM 5.2) and 23 other tissues.

Summary

This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FBXL19 Products(5)

mRNA Protein Name
NM_001099784.3 NP_001093254.2 F-box/LRR-repeat protein 19 isoform 1
NM_001282351.1 NP_001269280.1 F-box/LRR-repeat protein 19 isoform 3
NM_001382779.1 NP_001369708.1 F-box/LRR-repeat protein 19 isoform 4
NM_001382780.1 NP_001369709.1 F-box/LRR-repeat protein 19 isoform 5
NM_001382781.1 NP_001369710.1 F-box/LRR-repeat protein 19 isoform 6

FBXL19 Protein Structure

zf-CXXC

zf-CXXC: CXXC zinc finger domain (33 - 77)

F-box

F-box: F-box domain (424 - 463)

  • 0
  • 200
  • 400
  • 600
  • 694 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 19

jumonji C domain-containing histone demethylase 1C

Related Diseases

Diseases Alias
Psoriasis 10

PSORS10

Psoriasis Susceptibility 10

Psoriasis 10, Susceptibility To
Psoriasis 6

PSORS6

Psoriasis Susceptibility 6

Psoriasis 6, Susceptibility To
Psoriasis 2

PSORS2

Psoriasis

Psoriasis Vulgaris

Pv

Psoriasis, Susceptibility To, Type 2
Psoriasis
Psoriasis 3

PSORS3

Psoriasis Susceptibility 3

Psoriasis 3, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04788 FBXL19 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FBXL19 VGNC VGNC:59170
Canis familiaris FBXL19 VGNC VGNC:40759
Rattus norvegicus FBXL19 RGD RGD:1310989
Macaca mulatta FBXL19 VGNC VGNC:81406
Felis catus FBXL19 VGNC VGNC:80573
Mus musculus FBXL19 MGD MGI:3039600