BSPRY - B-box and SPRY domain containing Gene

Homo sapiens

Gene ID: 54836 | Gene type: protein coding

About BSPRY

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,349,541-113,371,222 (from NCBI)

This gene has 2 transcripts (splice variants), 119 orthologues and 80 paralogues. Broad expression in thyroid (RPKM 21.8), salivary gland (RPKM 19.5) and 16 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in cell leading edge; membrane; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BSPRY Products(3)

mRNA	Protein	Name
NM_001317943.2	NP_001304872.1	B box and SPRY domain-containing protein isoform 1
NM_001317944.2	NP_001304873.1	B box and SPRY domain-containing protein isoform 3
NM_017688.3	NP_060158.2	B box and SPRY domain-containing protein isoform 2

BSPRY Protein Structure

zf-B_box

PRY

SPRY

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

B box and SPRY domain-containing protein

B-box and SPRY-domain containing protein

Related Diseases

Diseases

Alias

Kleefstra Syndrome 1

9q Subtelomeric Deletion Syndrome	KLEFS1
Chromosome 9q34.3 Deletion Syndrome	9q- Syndrome
9q34 Deletion Syndrome	Kleefstra Syndrome Due To 9q34 Microdeletion
Kleefstra Syndrome	9q-Syndrome
9qstds	Kleefstra Syndrome Due To 9q Subtelomeric Deletion
Kleefstra Syndrome Due To Del(9)(Q34)	Kleefstra Syndrome Due To Monosomy 9q34
Chromosome 9q Subtelomeric Deletion Syndrome	Kleefstra Syndrome, Type 1

Parathyroid Adenoma

Adenoma Of Parathyroid	Adenoma Of The Parathyroid Gland
Parathyroid Gland Adenoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01647	BSPRY Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BSPRY	MGD	MGI:2177191
Canis familiaris	BSPRY	VGNC	VGNC:49718
Felis catus	BSPRY	VGNC	VGNC:60190
Macaca mulatta	BSPRY	VGNC	VGNC:70342
Rattus norvegicus	BSPRY	RGD	RGD:708400
Bos taurus	BSPRY	VGNC	VGNC:26580

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