PXK - PX domain containing serine/threonine kinase like Gene

Homo sapiens

Also known as SLOB; MONAKA

Gene ID: 54899 | Gene type: protein coding

About PXK

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:58,332,892-58,426,127 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues.

Summary

This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

PXK Products(58)

mRNA	Protein	Name
NM_001289095.2	NP_001276024.1	PX domain-containing protein kinase-like protein isoform b
NM_001289096.2	NP_001276025.1	PX domain-containing protein kinase-like protein isoform c
NM_001289098.2	NP_001276027.1	PX domain-containing protein kinase-like protein isoform d
NM_001289099.2	NP_001276028.1	PX domain-containing protein kinase-like protein isoform e
NM_001289100.2	NP_001276029.1	PX domain-containing protein kinase-like protein isoform f
NM_001289101.2	NP_001276030.1	PX domain-containing protein kinase-like protein isoform g
NM_001349488.2	NP_001336417.1	PX domain-containing protein kinase-like protein isoform d
NM_001349489.2	NP_001336418.1	PX domain-containing protein kinase-like protein isoform e
NM_001349490.2	NP_001336419.1	PX domain-containing protein kinase-like protein isoform f
NM_001349491.2	NP_001336420.1	PX domain-containing protein kinase-like protein isoform g
NM_001349492.2	NP_001336421.1	PX domain-containing protein kinase-like protein isoform h
NM_001349493.2	NP_001336422.1	PX domain-containing protein kinase-like protein isoform i
NM_001349494.2	NP_001336423.1	PX domain-containing protein kinase-like protein isoform j
NM_001349495.2	NP_001336424.1	PX domain-containing protein kinase-like protein isoform k
NM_001349496.2	NP_001336425.1	PX domain-containing protein kinase-like protein isoform jj
NM_001349497.2	NP_001336426.1	PX domain-containing protein kinase-like protein isoform l
NM_001349498.1	NP_001336427.1	PX domain-containing protein kinase-like protein isoform m
NM_001349499.2	NP_001336428.1	PX domain-containing protein kinase-like protein isoform n
NM_001349500.2	NP_001336429.1	PX domain-containing protein kinase-like protein isoform o
NM_001349501.2	NP_001336430.1	PX domain-containing protein kinase-like protein isoform p
NM_001349502.2	NP_001336431.1	PX domain-containing protein kinase-like protein isoform q
NM_001349503.2	NP_001336432.1	PX domain-containing protein kinase-like protein isoform r
NM_001349504.2	NP_001336433.1	PX domain-containing protein kinase-like protein isoform kk
NM_001349506.2	NP_001336435.1	PX domain-containing protein kinase-like protein isoform kk
NM_001349507.2	NP_001336436.1	PX domain-containing protein kinase-like protein isoform r
NM_001349508.2	NP_001336437.1	PX domain-containing protein kinase-like protein isoform s
NM_001349509.2	NP_001336438.1	PX domain-containing protein kinase-like protein isoform s
NM_001349510.2	NP_001336439.1	PX domain-containing protein kinase-like protein isoform t
NM_001349511.2	NP_001336440.1	PX domain-containing protein kinase-like protein isoform u
NM_001349512.2	NP_001336441.1	PX domain-containing protein kinase-like protein isoform ll
NM_001349513.2	NP_001336442.1	PX domain-containing protein kinase-like protein isoform mm
NM_001349514.2	NP_001336443.1	PX domain-containing protein kinase-like protein isoform nn
NM_001349515.2	NP_001336444.1	PX domain-containing protein kinase-like protein isoform v
NM_001349516.2	NP_001336445.1	PX domain-containing protein kinase-like protein isoform oo
NM_001349517.2	NP_001336446.1	PX domain-containing protein kinase-like protein isoform pp
NM_001349518.2	NP_001336447.1	PX domain-containing protein kinase-like protein isoform w
NM_001349519.2	NP_001336448.1	PX domain-containing protein kinase-like protein isoform x
NM_001349520.2	NP_001336449.1	PX domain-containing protein kinase-like protein isoform x
NM_001349521.2	NP_001336450.1	PX domain-containing protein kinase-like protein isoform qq
NM_001349522.2	NP_001336451.1	PX domain-containing protein kinase-like protein isoform y
NM_001349524.2	NP_001336453.1	PX domain-containing protein kinase-like protein isoform z
NM_001349525.2	NP_001336454.1	PX domain-containing protein kinase-like protein isoform aa
NM_001349526.2	NP_001336455.1	PX domain-containing protein kinase-like protein isoform bb
NM_001349527.2	NP_001336456.1	PX domain-containing protein kinase-like protein isoform cc
NM_001349528.2	NP_001336457.1	PX domain-containing protein kinase-like protein isoform dd
NM_001349529.2	NP_001336458.1	PX domain-containing protein kinase-like protein isoform dd
NM_001349530.2	NP_001336459.1	PX domain-containing protein kinase-like protein isoform ee
NM_001349531.2	NP_001336460.1	PX domain-containing protein kinase-like protein isoform rr
NM_001349532.2	NP_001336461.1	PX domain-containing protein kinase-like protein isoform ff
NM_001349533.2	NP_001336462.1	PX domain-containing protein kinase-like protein isoform gg
NM_001349534.2	NP_001336463.1	PX domain-containing protein kinase-like protein isoform gg
NM_001349535.2	NP_001336464.1	PX domain-containing protein kinase-like protein isoform hh
NM_001349536.2	NP_001336465.1	PX domain-containing protein kinase-like protein isoform hh
NM_001349537.2	NP_001336466.1	PX domain-containing protein kinase-like protein isoform ss
NM_001349538.2	NP_001336467.1	PX domain-containing protein kinase-like protein isoform ss
NM_001349539.2	NP_001336468.1	PX domain-containing protein kinase-like protein isoform ii
NM_001349540.2	NP_001336469.1	PX domain-containing protein kinase-like protein isoform ii
NM_017771.5	NP_060241.2	PX domain-containing protein kinase-like protein isoform a

PXK Protein Structure

Pkinase

WH2

0
100
200
300
400
500
578 a.a.

Protein Preferred Names

Protein Names

PX domain-containing protein kinase-like protein

PX ser/thr kinase v2

Related Diseases

Diseases

Alias

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11481	PXK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PXK	VGNC	VGNC:33583
Macaca mulatta	PXK	VGNC	VGNC:76522
Rattus norvegicus	PXK	RGD	RGD:727819
Felis catus	PXK	VGNC	VGNC:64448
Mus musculus	PXK	MGD	MGI:1289230
Canis familiaris	PXK	VGNC	VGNC:45219
Others	PXK	NCBI