PPP2R3C - protein phosphatase 2 regulatory subunit B''gamma Gene

Homo sapiens

Also known as G4-1; G5pr; GDRM; MEGD; SPGF36; C14orf10

Gene ID: 55012 | Gene type: protein coding

About PPP2R3C

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,085,472-35,122,298 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 18.2), bone marrow (RPKM 7.6) and 24 other tissues.

Summary

This gene encodes a regulatory subunit of the serine/threonine Phosphatase, protein Phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its Phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

PPP2R3C Products(3)

mRNA	Protein	Name
NM_001305155.2	NP_001292084.1	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2
NM_001305156.2	NP_001292085.1	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2
NM_017917.4	NP_060387.2	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 1

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

protein phosphatase 2 (formerly 2A), regulatory subunit B''

Related Diseases

Diseases

Alias

Spermatogenic Failure 36

SPGF36

Myoectodermal Gonadal Dysgenesis Syndrome

Gonadal Dysgenesis, Dysmorphic Facies, Retinal Dystrophy, And Myopathy	GDRM
MEGD	Brosnan-Kennerknecht-Guran-Koc Syndrome
Bkgk

Gonadal Dysgenesis

Gonadal Dysgenesis Syndrome

Turner Syndrome

Late Congenital Syphilis

Juvenile Neurosyphilis

Neurosyphilis, Juvenile

Omphalocele

Omphalocoele	Congenital Omphalocele
Exomphalos	Exumbilication

Spastic Paraplegia 9b, Autosomal Recessive

SPG9B	Autosomal Recessive Complex Spastic Paraplegia Type 9b
Hereditary Spastic Paraplegia 9b	Autosomal Recessive Spastic Paraplegia 9b
Autosomal Recessive Spastic Paraplegia Type 9b	Ar-Spg9b

Spastic Paraplegia 9a, Autosomal Dominant

Hereditary Spastic Paraplegia 9a	SPG9A
Cataracts With Motor Neuronopathy, Short Stature, And Skeletal Abnormalities	Ad-Spg9a
Spastic Paraparesis-Amyopathy-Cataracts-Gastroesophageal Reflux Syndrome	Spastic Paraparesis With Amyotrophy, Cataracts, And Gastroesophageal Reflux
Autosomal Dominant Complex Spastic Paraplegia Type 9a	Autosomal Dominant Spastic Paraplegia 9a
Cataracts Motor Neuropathy-Short Stature-Skeletal Anomalies Syndrome	Cataracts With Motor Neuronopathy, Short Stature And Skeletal Abnormalities
Spastic Paraparesis With Amyopathy, Cataracts And Gastroesophageal Reflux	Autosomal Dominant Spastic Paraplegia Type 9a
Cataracts-Motor Neuropathy-Short Stature-Skeletal Anomalies Syndrome	Spastic Paraparesis With Amyopathy, Cataracts, And Gastroesophageal Reflux
Spastic Paraplegia 9, Autosomal Dominant

Retinitis Pigmentosa 47

RP47	Retinitis Pigmentosa, Type 47

Skeletal Tuberculosis

Tuberculosis, Osteoarticular

Osteoarticular Tuberculosis

Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary	Malignant Ovarian Endometrioid Tumor
Ovarian Endometrioid Neoplasm

Holoprosencephaly 8

HPE8	Holoprosencephaly-8

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11017	PPP2R3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP2R3C	RGD	RGD:1309207
Macaca mulatta	PPP2R3C	VGNC	VGNC:76279
Mus musculus	PPP2R3C	MGD	MGI:1930009
Canis familiaris	PPP2R3C	VGNC	VGNC:44912
Bos taurus	PPP2R3C	VGNC	VGNC:33259
Felis catus	PPP2R3C	VGNC	VGNC:64327

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