2. Gene
  3. ARHGEF10L - Rho guanine nucleotide exchange factor 10 like Gene

ARHGEF10L - Rho guanine nucleotide exchange factor 10 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GrinchGEF

Gene ID: 55160 | Gene type: protein coding

About ARHGEF10L

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,513,435-17,697,875 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues, 2 paralogues and is associated with 76 phenotypes. Ubiquitous expression in kidney (RPKM 7.7), colon (RPKM 6.9) and 24 other tissues.

Summary

This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

ARHGEF10L Products(5)

mRNA Protein Name
NM_001011722.2 NP_001011722.2 rho guanine nucleotide exchange factor 10-like protein isoform 2
NM_001319837.1 NP_001306766.1 rho guanine nucleotide exchange factor 10-like protein isoform 3
NM_001319838.1 NP_001306767.1 rho guanine nucleotide exchange factor 10-like protein isoform 4
NM_001328124.1 NP_001315053.1 rho guanine nucleotide exchange factor 10-like protein isoform 5
NM_018125.4 NP_060595.3 rho guanine nucleotide exchange factor 10-like protein isoform 1

ARHGEF10L Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (323 - 502)

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  • 1279 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 10-like protein

Rho guanine nucleotide exchange factor (GEF) 10-like

Related Diseases

Diseases Alias
Post-Vaccinal Encephalitis

Encephalitis Following Immunization Procedures

Postvaccinal Encephalomyelitis

Encephalomyelitis, Acute Disseminated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00947 ARHGEF10L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF10L VGNC VGNC:38073
Macaca mulatta ARHGEF10L VGNC VGNC:69908
Bos taurus ARHGEF10L VGNC VGNC:26105
Rattus norvegicus ARHGEF10L RGD RGD:1585585
Felis catus ARHGEF10L VGNC VGNC:59897
Mus musculus ARHGEF10L MGD MGI:1920004