DOK4 - docking protein 4 Gene

Homo sapiens

Also known as IRS5; IRS-5

Gene ID: 55715 | Gene type: protein coding

About DOK4

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,471,922-57,487,322 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues and 7 paralogues. Ubiquitous expression in colon (RPKM 23.2), small intestine (RPKM 21.5) and 25 other tissues.

Summary

Predicted to be involved in positive regulation of MAPK cascade and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within nervous system development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DOK4 Products(16)

mRNA	Protein	Name
NM_001330556.2	NP_001317485.1	docking protein 4 isoform 2
NM_001369618.1	NP_001356547.1	docking protein 4 isoform 2
NM_001369619.1	NP_001356548.1	docking protein 4 isoform 1
NM_001369620.1	NP_001356549.1	docking protein 4 isoform 2
NM_001369621.1	NP_001356550.1	docking protein 4 isoform 1
NM_001394652.1	NP_001381581.1	docking protein 4 isoform 2
NM_001394653.1	NP_001381582.1	docking protein 4 isoform 2
NM_001394654.1	NP_001381583.1	docking protein 4 isoform 2
NM_001394655.1	NP_001381584.1	docking protein 4 isoform 2
NM_001394656.1	NP_001381585.1	docking protein 4 isoform 2
NM_001394657.1	NP_001381586.1	docking protein 4 isoform 1
NM_001394658.1	NP_001381587.1	docking protein 4 isoform 1
NM_001394659.1	NP_001381588.1	docking protein 4 isoform 1
NM_001394660.1	NP_001381589.1	docking protein 4 isoform 1
NM_001394661.1	NP_001381590.1	docking protein 4 isoform 1
NM_018110.5	NP_060580.2	docking protein 4 isoform 1

DOK4 Protein Structure

IRS

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

docking protein 4

downstream of tyrosine kinase 4

Related Diseases

Diseases

Alias

Nephronophthisis 3

NPHP3	Nph3
Adolescent Nephronophthisis	Nephronophthisis, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03936	DOK4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DOK4	VGNC	VGNC:40058
Bos taurus	DOK4	VGNC	VGNC:28168
Mus musculus	DOK4	MGD	MGI:2148865
Rattus norvegicus	DOK4	RGD	RGD:1310084
Felis catus	DOK4	VGNC	VGNC:61583
Macaca mulatta	DOK4	VGNC	VGNC:71867