ARFGAP1 - ADP ribosylation factor GTPase activating protein 1 Gene

Homo sapiens

Also known as ARF1GAP; HRIHFB2281

Gene ID: 55738 | Gene type: protein coding

About ARFGAP1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,272,813-63,289,790 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 11.8), testis (RPKM 11.1) and 25 other tissues.

Summary

The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ARFGAP1 Products(5)

mRNA	Protein	Name
NM_001281482.2	NP_001268411.1	ADP-ribosylation factor GTPase-activating protein 1 isoform c
NM_001281483.2	NP_001268412.1	ADP-ribosylation factor GTPase-activating protein 1 isoform d
NM_001281484.2	NP_001268413.1	ADP-ribosylation factor GTPase-activating protein 1 isoform e
NM_018209.4	NP_060679.1	ADP-ribosylation factor GTPase-activating protein 1 isoform a
NM_175609.3	NP_783202.1	ADP-ribosylation factor GTPase-activating protein 1 isoform b

ARFGAP1 Protein Structure

ArfGap

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor GTPase-activating protein 1

ARF1-directed GTPase-activating protein

Related Diseases

Diseases

Alias

Ceroid Lipofuscinosis, Neuronal, 4

Ceroid Lipofuscinosis, Neuronal, Parry Type	Cln4b Disease
Neuronal Ceroid Lipofuscinosis 4b	CLN4B
Autosomal Dominant Neuronal Ceroid Lipofuscinosis 4b	Ceroid Lipofuscinosis, Neuronal, 4b, Autosomal Dominant
Adult Neuronal Ceroid Lipofuscinosis	CLN4
Ceroid Lipofuscinosis, Neuronal, 4 , Autosomal Dominant	Neuronal Ceroid Lipofuscinosis 4
Neuronal Ceroid Lipofuscinosis 4 Parry Type	Adult Neuronal Ceroid Lipofuscinosis 4b
Kuf'S Disease Type B	Kuf'S Disease, Autosomal Dominant
Cln4 Disease	Parry Disease
Ceroid Lipofuscinosis, Neuronal 4	Ceroid Lipofuscinosis, Neuronal, 4b , Autosomal Dominant
Kufs Disease Autosomal Dominant	Neuronal Ceroid Lipofuscinosis Parry Type
Ceroid Lipofuscinosis, Neuronal, 4, Parry Type	Lipofuscinosis, Ceroid, Neuronal, Type 4, Parry Type

Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS	Hypotrichosis Lymphedema Telangiectasia Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome	Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12762	QS11	Inhibitor	99.22%	Unkown
HY-RS00899	ARFGAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARFGAP1	VGNC	VGNC:69835
Bos taurus	ARFGAP1	VGNC	VGNC:56176
Felis catus	ARFGAP1	VGNC	VGNC:59866
Mus musculus	ARFGAP1	MGD	MGI:2183559
Canis familiaris	ARFGAP1	VGNC	VGNC:38032
Rattus norvegicus	ARFGAP1	RGD	RGD:708452

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