RNF130 - ring finger protein 130 Gene

Homo sapiens

Also known as GP; G1RP; G1RZFP; GOLIATH

Gene ID: 55819 | Gene type: protein coding

About RNF130

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,911,651-180,071,759 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 9 paralogues. Ubiquitous expression in fat (RPKM 11.3), brain (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced Apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNF130 Products(3)

mRNA	Protein	Name
NM_001280801.2	NP_001267730.1	E3 ubiquitin-protein ligase RNF130 isoform 2 precursor
NM_001410829.1	NP_001397758.1	E3 ubiquitin-protein ligase RNF130 isoform 3 precursor
NM_018434.6	NP_060904.2	E3 ubiquitin-protein ligase RNF130 isoform 1 precursor

RNF130 Protein Structure

zf-RING_2

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF130

RING-type E3 ubiquitin transferase RNF130

Related Diseases

Diseases

Alias

Pilocytic Astrocytoma Of Cerebellum

Cerebellar Pilocytic Astrocytoma

Cerebellar Astrocytoma

Astrocytoma Of Cerebellum

Pilomyxoid Astrocytoma

Cerebellum Cancer

Cerebellar Neoplasms	Cerebellar Cancer
Malignant Tumor Of Cerebellum	Malignant Neoplasm Of Cerebellum

Dysembryoplastic Neuroepithelial Tumor

Dysembryoplastic Neuroepithelial Tumour	Dysembryoplastic Neuroepithelial Neoplasm
Dnet

Papillary Craniopharyngioma

Craniopharyngioma, Papillary	Papillary Rathke'S Pouch Tumor
Craniopharyngioma Papillary

Childhood Pilocytic Astrocytoma

Pediatric Pilocytic Astrocytoma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12048	RNF130 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNF130	VGNC	VGNC:64670
Bos taurus	RNF130	VGNC	VGNC:34021
Macaca mulatta	RNF130	VGNC	VGNC:76764
Mus musculus	RNF130	MGD	MGI:1891717
Rattus norvegicus	RNF130	RGD	RGD:1562041
Canis familiaris	RNF130	VGNC	VGNC:45630

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