2. Gene
  3. PRKCZ - protein kinase C zeta Gene

PRKCZ - protein kinase C zeta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PKC2; PKC-ZETA

Gene ID: 5590 | Gene type: protein coding

About PRKCZ

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:2,048,504-2,185,395 (from NCBI)

This gene has 26 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues.

Summary

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKCZ Products(35)

mRNA Protein Name
NR_146911.2
XM_017001789.2 XP_016857278.1 protein kinase C zeta type isoform X1
XM_024448396.2 XP_024304164.1 protein kinase C zeta type isoform X14
XM_011541776.2 XP_011540078.1 protein kinase C zeta type isoform X14
XR_007061965.1
XR_007061966.1
XM_017001803.3 XP_016857292.1 protein kinase C zeta type isoform X18
XM_024448397.2 XP_024304165.1 protein kinase C zeta type isoform X16
NM_001350805.2 NP_001337734.1 protein kinase C zeta type isoform 5
XM_017001793.2 XP_016857282.1 protein kinase C zeta type isoform X10
XM_047425273.1 XP_047281229.1 protein kinase C zeta type isoform X7
XM_047425260.1 XP_047281216.1 protein kinase C zeta type isoform X5
XM_047425262.1 XP_047281218.1 protein kinase C zeta type isoform X6
XM_011541775.4 XP_011540077.1 protein kinase C zeta type isoform X13
XM_047425304.1 XP_047281260.1 protein kinase C zeta type isoform X10
XM_017001802.2 XP_016857291.1 protein kinase C zeta type isoform X17
NM_001242874.3 NP_001229803.1 protein kinase C zeta type isoform 3
XM_017001797.2 XP_016857286.1 protein kinase C zeta type isoform X12
XM_047425348.1 XP_047281304.1 protein kinase C zeta type isoform X15
NM_001350803.2 NP_001337732.1 protein kinase C zeta type isoform 4
XM_047425323.1 XP_047281279.1 protein kinase C zeta type isoform X11
XM_024448391.2 XP_024304159.1 protein kinase C zeta type isoform X10
XM_017001792.2 XP_016857281.1 protein kinase C zeta type isoform X10
XM_017001790.2 XP_016857279.1 protein kinase C zeta type isoform X2
XM_047425307.1 XP_047281263.1 protein kinase C zeta type isoform X10
XM_011541773.2 XP_011540075.1 protein kinase C zeta type isoform X3
XM_047425340.1 XP_047281296.1 protein kinase C zeta type isoform X14
XM_047425255.1 XP_047281211.1 protein kinase C zeta type isoform X4
XM_011541774.2 XP_011540076.1 protein kinase C zeta type isoform X8
XM_047425283.1 XP_047281239.1 protein kinase C zeta type isoform X9
NM_001033581.3 NP_001028753.1 protein kinase C zeta type isoform 2
NM_001350806.2 NP_001337735.1 protein kinase C zeta type isoform 5
NM_001033582.3 NP_001028754.1 protein kinase C zeta type isoform 2
NM_002744.6 NP_002735.3 protein kinase C zeta type isoform 1
NM_001350804.2 NP_001337733.1 protein kinase C zeta type isoform 4

PRKCZ Protein Structure

PB1

PB1: PB1 domain (16 - 97)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (131 - 182)

Pkinase

Pkinase: Protein kinase domain (253 - 503)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (540 - 583)

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  • 592 a.a.
Protein Preferred Names Protein Names

protein kinase C zeta type

nPKC-zeta

Related Diseases

Diseases Alias
Diabetes Mellitus

Diabetes
Combined Oxidative Phosphorylation Deficiency 33

COXPD33
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11141 PRKCZ Human Pre-designed siRNA Set A / Unkown
HY-RS11142 Prkcz Mouse Pre-designed siRNA Set A / Unkown
HY-RS11143 Prkcz Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRKCZ VGNC VGNC:33336
Felis catus PRKCZ VGNC VGNC:80323
Mus musculus PRKCZ MGD MGI:97602
Macaca mulatta PRKCZ VGNC VGNC:82212
Rattus norvegicus PRKCZ RGD RGD:3399
Canis familiaris PRKCZ VGNC VGNC:44985
Others PRKCZ NCBI