2. Gene
  3. METTL3 - methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Gene

METTL3 - methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as M6A; IME4; Spo8; MT-A70; hMETTL3

Gene ID: 56339 | Gene type: protein coding

About METTL3

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,498,138-21,511,340 (from NCBI)

This gene has 14 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in lymph node (RPKM 23.5), testis (RPKM 22.1) and 25 other tissues.

Summary

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This Enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

METTL3 Products(1)

mRNA Protein Name
NM_019852.5 NP_062826.2 N6-adenosine-methyltransferase catalytic subunit

METTL3 Protein Structure

MT-A70

MT-A70: MT-A70 (389 - 550)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
Protein Preferred Names Protein Names

N6-adenosine-methyltransferase catalytic subunit

N6-adenosine-methyltransferase 70 kDa subunit

Related Diseases

Diseases Alias
Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Bladder

Transitional Cell Carcinoma Of The Bladder

Urinary Bladder Urothelial Carcinoma

Urothelial Bladder Carcinoma

Carcinoma Transitional Cell Bladder

Tcc - [Transitional Cell Carcinoma] Of Bladder
Hepatoblastoma
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Ocular Melanoma

Intraocular Melanoma

Uveal Melanoma

Eye Melanoma

Melanoma Of Eye

Melanoma Of The Uvea

Malignant Melanoma Of Eye
Retinitis Pigmentosa 11

RP11

Retinitis Pigmentosa-11

Retinitis Pigmentosa, Type 11
Cervix Carcinoma

Cancer Of Cervix

Carcinoma Of Cervix

Carcinoma Cervix Uteri

Carcinoma Of The Cervix Uteri
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-134836 STM2457 Inducer 99.87% Unkown
HY-19528 SAH 99.89% Unkown
HY-134673A UZH1a Inducer 98.86% Unkown
HY-156677 STC-15 Inhibitor 99.36% Unkown
HY-115717 UZH2 Inhibitor 98.73% Unkown
HY-19528S SAH-d4 ≥99.0% Unkown
HY-156773 STM3006 97.16% Unkown
HY-134673 UZH1 Inducer 99.88% Unkown
HY-153625 STM2120 Inhibitor 99.92% Unkown
HY-134673B UZH1b Inhibitor 99.75% Unkown
HY-160415A WD6305 TFA 98.47% Unkown
HY-162082 METTL1-WDR4-IN-2 Inhibitor 98.12% Unkown
HY-19528S2 SAH-13C10 / Unkown
HY-148467 METTL3-IN-1 Inhibitor / Unkown
HY-148468 METTL3-IN-2 Inhibitor / Unkown
HY-148469 METTL3-IN-3 Inhibitor / Unkown
HY-151924 Antiviral agent 23 Inhibitor / Unkown
HY-151926 Antiviral agent 24 Inhibitor 99.63% Unkown
HY-154997 7OQL Inhibitor / Unkown
HY-156759 METTL3-IN-5 Inhibitor / Unkown
HY-160415 WD6305 / Unkown
HY-162282 PROTAC METTL3-14 degrader 1 Degrader / Unkown
HY-19528S1 SAH-13C5 / Unkown
HY-RS08364 METTL3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus METTL3 VGNC VGNC:63465
Mus musculus METTL3 MGD MGI:1927165
Rattus norvegicus METTL3 RGD RGD:1311750
Canis familiaris METTL3 VGNC VGNC:43177
Bos taurus METTL3 VGNC VGNC:31412