KCNK12 - potassium two pore domain channel subfamily K member 12 Gene

Homo sapiens

Also known as THIK2; THIK-2; K2p12.1

Gene ID: 56660 | Gene type: protein coding

About KCNK12

Cytogenetic location: 2p16.3 Genomic coordinates (GRCh38): 2:47,509,290-47,570,985 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 14 paralogues. Biased expression in brain (RPKM 1.7), placenta (RPKM 0.4) and 8 other tissues.

Summary

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

KCNK12 Products(1)

mRNA	Protein	Name
NM_022055.2	NP_071338.1	potassium channel subfamily K member 12

KCNK12 Protein Structure

Ion_trans_2

0
100
200
300
400
430 a.a.

Protein Preferred Names

Protein Names

potassium channel subfamily K member 12

potassium channel, subfamily K, member 12

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 52

DEE52	Epileptic Encephalopathy, Early Infantile, 52
Eiee52	Developmental And Epileptic Encephalopathy, 52
Early Infantile Epileptic Encephalopathy 52

Skin Angiosarcoma

Angiosarcoma Of Skin	Hemangiosarcoma Of The Skin
Haemangiosarcoma Of Skin	Lymphangiosarcoma Of Skin
Cutaneous Angiosarcoma	Malignant Haemangioendothelioma Of Skin

Brugada Syndrome 5

BRGDA5	Cardiac Conduction Defect, Nonspecific
Brugada Syndrome, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07154	KCNK12 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNK12	VGNC	VGNC:42271
Macaca mulatta	KCNK12	VGNC	VGNC:106176
Bos taurus	KCNK12	VGNC	VGNC:30467
Rattus norvegicus	KCNK12	RGD	RGD:68940
Mus musculus	KCNK12	MGD	MGI:2684043

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