2. Gene
  3. Mtor - mechanistic target of rapamycin kinase Gene

Mtor - mechanistic target of rapamycin kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; 2610315D21Rik

Gene ID: 56717 | Gene type: protein coding

About Mtor

Chromosome 4: 148,533,068-148,642,140 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 64 phenotypes. Ubiquitous expression in testis adult (RPKM 23.), kidney adult (RPKM 12.8) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human mTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mtor Products(1)

mRNA Protein Name
NM_020009.2 NP_064393.2 serine/threonine-protein kinase mTOR

Mtor Protein Structure

TEL1

TEL1: COG5032 (362 - 2548)

HEAT

HEAT: sd00044 (654 - 680)

HEAT

HEAT: sd00044 (690 - 720)

HEAT

HEAT: sd00044 (728 - 758)

HEAT

HEAT: sd00044 (771 - 804)

HEAT

HEAT: sd00044 (816 - 846)

HEAT

HEAT: sd00044 (954 - 980)

HEAT

HEAT: sd00044 (992 - 1020)

HEAT

HEAT: sd00044 (1032 - 1061)

HEAT

HEAT: sd00044 (1072 - 1098)

HEAT

HEAT: sd00044 (1110 - 1141)

HEAT

HEAT: sd00044 (1153 - 1179)

  • 0
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  • 800
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  • 2000
  • 2400
  • 2549 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase mTOR

FK506 binding protein 12-rapamycin associated protein 1

FK506-binding protein 12-rapamycin complex-associated protein 1

FKBP-rapamycin associated protein (FRAP)

FKBP12-rapamycin complex-associated protein

angiopoietin-like factor CDT6

mammalian target of rapamycin

mechanistic target of rapamycin (serine/threonine kinase)

rapamycin target protein 1

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10219 Rapamycin Inhibitor 99.94% Yes
HY-10218 Everolimus Inhibitor 99.85% Yes
HY-50910 Temsirolimus Inhibitor 99.56% Yes
HY-N0486 L-Leucine Activator 99.79% Unkown
HY-N0281 Daphnetin Inhibitor 99.86% Unkown
HY-B0725A Doxepin / Unkown
HY-B1232A Metyrapone Tartrate Modulator / Unkown
HY-10218R Everolimus (Standard) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (30)
Cat. No. Product Name Effect
Purity Phase
HY-50673 Dactolisib Inhibitor 99.94% Phase 3
HY-50908 Ridaforolimus Inhibitor 99.20% Phase 3
HY-15174 Dactolisib Tosylate Inhibitor 99.87% Phase 3
HY-B1787 Sulindac sulfone Inhibitor 98.08% Phase 3
HY-13328 Sapanisertib Inhibitor 99.66% Phase 2
HY-139609 Camonsertib Inhibitor 99.75% Phase 2
HY-N0112 Dihydromyricetin Inhibitor 98.10% Phase 2
HY-114384 NV-5138 Activator ≥98.0% Phase 2
HY-15247 Vistusertib Inhibitor 98.21% Phase 2
HY-15177 PF-04691502 Inhibitor 99.91% Phase 2
HY-12513 Samotolisib Inhibitor 99.42% Phase 2
HY-114384B NV-5138 hydrochloride Activator ≥98.0% Phase 2
HY-15900 Voxtalisib Inhibitor 98.81% Phase 2
HY-13246 Apitolisib Inhibitor 99.65% Phase 2
HY-12868 Bimiralisib Inhibitor 99.80% Phase 2
HY-13334 BGT226 maleate Inhibitor 99.87% Phase 2
HY-16956 Onatasertib Inhibitor ≥97.0% Phase 2
HY-13334A BGT226 Inhibitor 99.51% Phase 2
HY-19962 Paxalisib Inhibitor 99.74% Phase 2
HY-13691 MKC-1 Inhibitor 99.23% Phase 2
HY-10422 AZD-8055 Inhibitor 99.60% Phase 1
HY-10297 Omipalisib Inhibitor 99.93% Phase 1
HY-132168 RMC-5552 Inhibitor 98.10% Phase 1
HY-16962 CC-115 Inhibitor 95.76% Phase 1
HY-12036 GSK1059615 Inhibitor ≥99.0% Phase 1
HY-10423 OSI-027 Inhibitor 99.40% Phase 1
HY-16585 VS-5584 Inhibitor 99.14% Phase 1
HY-16962A CC-115 hydrochloride Inhibitor 98.03% Phase 1
HY-15248 GDC-0349 Inhibitor 96.46% Phase 1
HY-14581 Palomid 529 Inhibitor 99.47% Phase 1
Pre-clinical Phase
Bioactive Molecules (176)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0795 MHY1485 Activator 99.86% Unkown
HY-13003 Torin 1 Inhibitor 99.08% Unkown
HY-N0109 Salidroside Activator 99.79% Unkown
HY-13002 Torin 2 Inhibitor 99.98% Unkown
HY-122022 JR-AB2-011 Inhibitor 99.16% Unkown
HY-U00434 3BDO Activator 99.91% Unkown
HY-10474 Torkinib Inhibitor 98.37% Unkown
HY-111373 RapaLink-1 Inhibitor 99.27% Unkown
HY-10115 PI-103 Inhibitor 98.93% Unkown
HY-100542 D-α-Hydroxyglutaric acid disodium Inhibitor ≥98.0% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.81% Unkown
HY-124798 Rheb inhibitor NR1 Inhibitor 99.46% Unkown
HY-N0047 Polyphyllin I Inhibitor 99.61% Unkown
HY-10681 Gedatolisib Inhibitor 99.68% Unkown
HY-N0189 Aloe emodin Inhibitor 98.32% Unkown
HY-50710 KU-0063794 Inhibitor 99.55% Unkown
HY-N0787 Cryptochlorogenic acid Inhibitor 99.88% Unkown
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.81% Unkown
HY-10044 WYE-132 Inhibitor 99.40% Unkown
HY-134904 RMC-6272 Inhibitor 95.54% Unkown
HY-13431 KU-0060648 Inhibitor 99.62% Unkown
HY-10372 PP121 Inhibitor 98.67% Unkown
HY-115449 Chromeceptin p53 Inhibitor 99.91% Unkown
HY-10683 PKI-402 Inhibitor 98.43% Unkown
HY-100222 CZ415 Inhibitor 98.74% Unkown
HY-W016412 Coenzyme Q0 Inhibitor 99.88% Unkown
HY-N0486S1 L-Leucine-13C Activator ≥98.00% Unkown
HY-18353 mTOR inhibitor-3 Inhibitor 99.09% Unkown
HY-146751 PI3K/Akt/mTOR-IN-2 Inhibitor 99.86% Unkown
HY-N0486S9 L-Leucine-d3 Activator ≥98.0% Unkown
HY-N6626 Pyraclostrobin 99.91% Unkown
HY-107365 PQR530 Inhibitor 99.98% Unkown
HY-12034 WYE-354 Inhibitor 98.04% Unkown
HY-N0656A (+)-Usnic acid Inhibitor 99.63% Unkown
HY-12763 GNE-317 Inhibitor 99.14% Unkown
HY-10219S Rapamycin-d3 Inhibitor 95.48% Unkown
HY-N6996 Methyl Eugenol Inhibitor 98.64% Unkown
HY-10115A PI-103 Hydrochloride Inhibitor 98.00% Unkown
HY-100026 PQR620 Inhibitor 98.01% Unkown
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 98.21% Unkown
HY-15272 WAY-600 Inhibitor 99.75% Unkown
HY-N2217 Rotundic acid Inhibitor 99.41% Unkown
HY-109046 Tulrampator 98.92% Unkown
HY-W058849 MT 63-78 Inhibitor 98.50% Unkown
HY-137175 TMBIM6 antagonist-1 Antagonist 99.60% Unkown
HY-110109 ETP-45658 Inhibitor 98.05% Unkown
HY-N0486S3 L-Leucine-15N Activator ≥98.0% Unkown
HY-N0107 Cyclovirobuxine D Inhibitor ≥98.0% Unkown
HY-15521 ETP-46464 Inhibitor 99.55% Unkown
HY-W592871 10-Hydroxy-2-decenoic acid 99.99% Unkown
HY-100470 NSC781406 Inhibitor 99.97% Unkown
HY-N0486S L-Leucine-d10 Activator ≥98.0% Unkown
HY-112914 mTOR inhibitor-1 Inhibitor 99.50% Unkown
HY-15271 WYE-687 Inhibitor 98.05% Unkown
HY-111508 PI3K/mTOR Inhibitor-2 Inhibitor 98.25% Unkown
HY-11080 PKI-179 Inhibitor ≥98.0% Unkown
HY-128333 PI3K/mTOR Inhibitor-4 Inhibitor 97.00% Unkown
HY-11042 GNE-477 Inhibitor 98.70% Unkown
HY-13806 XL388 Inhibitor 99.74% Unkown
HY-10811 GNE-493 Inhibitor 98.33% Unkown
HY-137315 TML-6 Inhibitor 99.01% Unkown
HY-136660 PQR626 Inhibitor 98.05% Unkown
HY-100398 PF-04979064 Inhibitor 99.30% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-141805 MHY-1685 Inhibitor 99.97% Unkown
HY-N6950 Hederacolchiside A1 Modulator 99.69% Unkown
HY-N0486S12 L-Leucine-d2 Activator ≥99.0% Unkown
HY-N6843 Arnicolide D Inhibitor 99.20% Unkown
HY-N0486S8 L-Leucine-13C6,15N Activator 99.90% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-118717 mTOR inhibitor WYE-28 Inhibitor 99.75% Unkown
HY-134903 (32-Carbonyl)-RMC-5552 Inhibitor 95.04% Unkown
HY-11080A PKI-179 hydrochloride Inhibitor 98.11% Unkown
HY-N0486S2 L-Leucine-13C6 Activator ≥98.0% Unkown
HY-153120A PI3K/mTOR Inhibitor-13 sodium Inhibitor 98.13% Unkown
HY-145931 CC214-2 Inhibitor 98.41% Unkown
HY-114267 Cbz-B3A Inhibitor ≥98.0% Unkown
HY-126077 MTI-31 Inhibitor 99.94% Unkown
HY-10812 GNE-490 Inhibitor 96.29% Unkown
HY-111065 OXA-01 Inhibitor / Unkown
HY-151622 PI3K/mTOR Inhibitor-11 Inhibitor 98.74% Unkown
HY-143510 RMC-4627 / Unkown
HY-131344 mTOR inhibitor-8 Inhibitor 98.04% Unkown
HY-124036 DS-7423 Inhibitor 99.75% Unkown
HY-N4315 Pomiferin Inhibitor 97.36% Unkown
HY-N2590 Lupenone ≥98.0% Unkown
HY-N1050 Zederone Inhibitor 97.75% Unkown
HY-124582 NEO214 Activator ≥98.0% Unkown
HY-15271A WYE-687 dihydrochloride Inhibitor ≥98.0% Unkown
HY-162382 KTC1101 Inhibitor / Unkown
HY-12652 AZD3147 Inhibitor 99.93% Unkown
HY-163199 ASCT2-IN-2 Inhibitor / Unkown
HY-157169 IBL-302 Inhibitor / Unkown
HY-125927 8-Aminoadenosine Inhibitor 99.94% Unkown
HY-101776A Desmethyl-VS-5584 hydrochloride Inhibitor 98.63% Unkown
HY-10219GL Rapamycin (GMP Like) Inhibitor / Unkown
HY-151137 HSP90/mTOR-IN-1 Inhibitor / Unkown
HY-112602 PI3K/mTOR Inhibitor-1 Inhibitor / Unkown
HY-107363 FT-1518 Inhibitor 98.14% Unkown
HY-111370 mTOR inhibitor-2 Inhibitor / Unkown
HY-10218S Everolimus-d4 Inhibitor / Unkown
HY-N0486S11 L-Leucine-d1 Activator / Unkown
HY-147284 PI3K-IN-37 Inhibitor / Unkown
HY-147285 PI3K/mTOR Inhibitor-9 Inhibitor / Unkown
HY-10620 PI3K-IN-22 Inhibitor / Unkown
HY-127067 Yuanhuadin Inhibitor / Unkown
HY-154958 mTOR inhibitor-12 Inhibitor / Unkown
HY-146016 PI3K/mTOR Inhibitor-5 Inhibitor / Unkown
HY-123849 SN32976 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-144686 ATM Inhibitor-3 Inhibitor / Unkown
HY-115869 RMC-4529 Inhibitor / Unkown
HY-N0486S6 L-Leucine-2-13C,15N Activator / Unkown
HY-137996 Dehydrovomifoliol Inhibitor / Unkown
HY-15281 QL-IX-55 Inhibitor / Unkown
HY-144687 ATM Inhibitor-4 Inhibitor / Unkown
HY-13847 GNE-555 Inhibitor / Unkown
HY-N6626R Pyraclostrobin (Standard) / Unkown
HY-N0109R Salidroside (Standard) Activator / Unkown
HY-128027 eCF309 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-141476 PI3K/mTOR Inhibitor-3 Inhibitor / Unkown
HY-144295 PI3Kα-IN-5 Inhibitor / Unkown
HY-154957 mTOR inhibitor-11 Inhibitor / Unkown
HY-N10754 Aschantin Inhibitor / Unkown
HY-155376 mTOR inhibitor-14 Inhibitor / Unkown
HY-137315S TML-6-d3 / Unkown
HY-15269 PP30 Inhibitor / Unkown
HY-N0486S4 L-Leucine-d7 Activator / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-N3628 Coronarin A Inhibitor / Unkown
HY-109633 PI3K-IN-18 Inhibitor / Unkown
HY-163511 PI3K/Akt/mTOR-IN-4 Inhibitor / Unkown
HY-113038 D-α-Hydroxyglutaric acid Inhibitor / Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.84% Unkown
HY-152238 PI3K/mTOR Inhibitor-12 Inhibitor / Unkown
HY-150061 NVP-BBD130 Inhibitor / Unkown
HY-155066 FD274 Inhibitor / Unkown
HY-15268 PP487 Inhibitor / Unkown
HY-163198 ASCT2-IN-1 Inhibitor / Unkown
HY-P5984A Thioether-cyclized helix B peptide, CHBP TFA Inhibitor / Unkown
HY-146200 PI3K/mTOR Inhibitor-8 Inhibitor / Unkown
HY-119665 Asteltoxin Inhibitor / Unkown
HY-N0486S10 L-Leucine-18O2 Activator / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-147913 PI3K/Akt/mTOR-IN-3 Inhibitor / Unkown
HY-154910 CC214-1 Inhibitor / Unkown
HY-121726 3HOI-BA-01 Inhibitor / Unkown
HY-15901A LGB321 monohydrochloride Inhibitor / Unkown
HY-N0486S13 L-Leucine-15N,d10 / Unkown
HY-139832 MCX 28 Inhibitor / Unkown
HY-N1244 Sarmentosin Inhibitor / Unkown
HY-101776 Desmethyl-VS-5584 Inhibitor / Unkown
HY-N0486S5 L-Leucine-2-13C Activator / Unkown
HY-156445 PI3K/mTOR Inhibitor-14 Inhibitor / Unkown
HY-144449 mTOR/HDAC6-IN-1 Inhibitor / Unkown
HY-N2517 Dihydroevocarpine Inhibitor 99.62% Unkown
HY-147614 PI3K/mTOR Inhibitor-7 Inhibitor / Unkown
HY-103438 BIBU1361 / Unkown
HY-N1338 Royleanone Inhibitor / Unkown
HY-P5984 Thioether-cyclized helix B peptide, CHBP Inhibitor / Unkown
HY-118712 mTOR inhibitor WYE-23 Inhibitor / Unkown
HY-162147 Nur77 modulator 3 Inhibitor / Unkown
HY-160548 mTOR inhibitor-18 Inhibitor / Unkown
HY-162143 SKI-349 Inhibitor 99.58% Unkown
HY-156432 ALK-IN-26 Inhibitor 99.87% Unkown
HY-147613 PI3K/mTOR Inhibitor-6 Inhibitor / Unkown
HY-118704 P-2281 Inhibitor / Unkown
HY-10116 PI-540 Inhibitor / Unkown
HY-N0486S7 L-Leucine-1-13C,15N Activator ≥98.0% Unkown
HY-153120 PI3K/mTOR Inhibitor-13 Inhibitor / Unkown
HY-155211 mTOR inhibitor-13 Inhibitor / Unkown
HY-155475 mTORC1-IN-2 Inhibitor / Unkown
HY-157167 mTORC1-IN-1 / Unkown
HY-U00326 PI3Kα/mTOR-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtor NCBI NCBI:2475