2. Gene
  3. DHX35 - DEAH-box helicase 35 Gene

DHX35 - DEAH-box helicase 35 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DDX35; C20orf15; KAIA0875

Gene ID: 60625 | Gene type: protein coding

About DHX35

This gene has 8 transcripts (splice variants), 200 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 6.1), endometrium (RPKM 6.0) and 25 other tissues.

Summary

DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]

DHX35 Products(2)

mRNA Protein Name
NM_001190809.2 NP_001177738.1 probable ATP-dependent RNA helicase DHX35 isoform 2
NM_021931.4 NP_068750.2 probable ATP-dependent RNA helicase DHX35 isoform 1

DHX35 Protein Structure

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (307 - 397)

HA2

HA2: Helicase associated domain (HA2) (458 - 549)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (584 - 684)

  • 0
  • 200
  • 400
  • 600
  • 703 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DHX35

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 35

Related Diseases

Diseases Alias
Cranioectodermal Dysplasia 2

CED2

Sensenbrenner Syndrome 2

Dysplasia, Cranioectodermal, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03754 DHX35 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DHX35 VGNC VGNC:39945
Rattus norvegicus DHX35 RGD RGD:1311165
Mus musculus DHX35 MGD MGI:1918965
Felis catus DHX35 VGNC VGNC:61480
Bos taurus DHX35 VGNC VGNC:28053