2. Gene
  3. SEMG1 - semenogelin 1 (the main protein of the human semen coagulum) Gene

SEMG1 - semenogelin 1 (the main protein of the human semen coagulum) Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SGI; SEMG; CT103; dJ172H20.2

Gene ID: 6406 | Gene type: protein coding

About SEMG1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,207,033-45,209,768 (from NCBI)

This gene has 1 transcript (splice variant), 29 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these Peptides, SgI-29, is an antimicrobial peptide with Antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]

SEMG1 Products(1)

mRNA Protein Name
NM_003007.5 NP_002998.1 semenogelin-1 preproprotein

SEMG1 Protein Structure

Semenogelin

Semenogelin: Semenogelin (1 - 371)

Semenogelin

Semenogelin: Semenogelin (283 - 461)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

semenogelin-1

SgI-29

Recombinant SEMG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71287 Semenogelin-1 Protein, Human (HEK293, His) AAH07096.1 (Q24-T402) ≥95%

Related Diseases

Diseases Alias
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein
Infertility
Epididymis Disease
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12669 SEMG1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SEMG1 RGD RGD:3790
Others SEMG1 NCBI