NPAS3 - neuronal PAS domain protein 3 Gene

Homo sapiens

Also known as MOP6; PASD6; bHLHe12

Gene ID: 64067 | Gene type: protein coding

About NPAS3

Cytogenetic location: 14q13.1 Genomic coordinates (GRCh38): 14:32,934,785-33,804,173 (from NCBI)

This gene has 16 transcripts (splice variants), 208 orthologues and 7 paralogues. Biased expression in brain (RPKM 3.9), endometrium (RPKM 1.3) and 4 other tissues.

Summary

This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and cognitive disability. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

NPAS3 Products(6)

mRNA	Protein	Name
NM_001164749.2	NP_001158221.1	neuronal PAS domain-containing protein 3 isoform 1
NM_001165893.2	NP_001159365.1	neuronal PAS domain-containing protein 3 isoform 4
NM_001394988.1	NP_001381917.1	neuronal PAS domain-containing protein 3 isoform 5
NM_001394989.1	NP_001381918.1	neuronal PAS domain-containing protein 3 isoform 6
NM_022123.3	NP_071406.1	neuronal PAS domain-containing protein 3 isoform 2
NM_173159.3	NP_775182.1	neuronal PAS domain-containing protein 3 isoform 3

NPAS3 Protein Structure

PAS

PAS_3

0
200
400
600
800
933 a.a.

Protein Preferred Names

Protein Names

neuronal PAS domain-containing protein 3

PAS domain-containing protein 6

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Schizophrenia 15

SCZD15	Schizophrenia 15 With Or Without An Affective Disorder
Schizophrenia Susceptibility Locus, Chromosome 22q13-Related	Schizophrenia Susceptibility Locus Chromosome 22q13-Related
Schizophrenia, Type 15

Schizophrenia 18

SCZD18	Schizophrenia 18 With Or Without An Affective Disorder
Schizophrenia Susceptibility 18	Chromosome 7q36.3 Duplication Syndrome, 362-Kb
Schizophrenia, Type 18

Chromosome 14q11-Q22 Deletion Syndrome

14q11.2 Microdeletion Syndrome	Zahir-Friedman Syndrome
Del(14)(Q11.2)	Monosomy 14q11.2

Holoprosencephaly 8

HPE8	Holoprosencephaly-8

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Sotos Syndrome

Cerebral Gigantism	SOTOS
Chromosome 5q35 Deletion Syndrome	Sotos Syndrome 1, Formerly
Sotos1, Formerly	Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development
Sotos Sequence	Sotos' Syndrome
Sotos1	Sotos Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112374	NPAS3-IN-1		98.29%	Unkown
HY-RS09470	NPAS3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NPAS3	VGNC	VGNC:75213
Mus musculus	NPAS3	MGD	MGI:1351610
Bos taurus	NPAS3	VGNC	VGNC:59355
Felis catus	NPAS3	VGNC	VGNC:104572
Rattus norvegicus	NPAS3	RGD	RGD:1307181
Canis familiaris	NPAS3	VGNC	VGNC:56062

Name
Email *

	Sorry, but the email address you supplied was invalid.