ECSCR - endothelial cell surface expressed chemotaxis and apoptosis regulator Gene

Homo sapiens

Also known as ARIA; ECSM2

Gene ID: 641700 | Gene type: protein coding

About ECSCR

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,448,560-139,462,743 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 92 orthologues. Broad expression in placenta (RPKM 24.9), lung (RPKM 23.6) and 22 other tissues.

Summary

The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ECSCR Products(2)

mRNA	Protein	Name
NM_001077693.4	NP_001071161.1	endothelial cell-specific chemotaxis regulator isoform 1 precursor
NM_001293739.2	NP_001280668.1	endothelial cell-specific chemotaxis regulator isoform 2 precursor

Protein Preferred Names

Protein Names

endothelial cell-specific chemotaxis regulator

apoptosis regulator through modulating IAP expression

Recombinant ECSCR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77919	ECSCR Protein, Human (HEK293, Fc)	Q19T08 (Q25-A124)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04147	ECSCR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ECSCR	RGD	RGD:1594804
Mus musculus	ECSCR	MGD	MGI:1915795

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