RNF25 - ring finger protein 25 Gene

Homo sapiens

Also known as AO7

Gene ID: 64320 | Gene type: protein coding

About RNF25

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,663,892-218,672,002 (from NCBI)

This gene has 6 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 11.2), thyroid (RPKM 8.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

RNF25 Products(1)

mRNA	Protein	Name
NM_022453.3	NP_071898.2	E3 ubiquitin-protein ligase RNF25

RNF25 Protein Structure

RWD

zf-RING_2

0
100
200
300
400
459 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF25

RING-type E3 ubiquitin transferase RNF25

Related Diseases

Diseases

Alias

Hypomagnesemia 3, Renal

HOMG3	Renal Hypomagnesemia 3
Fhhnc Without Severe Ocular Involvement	Renal Hypomagnesemia Type 3
Hypomagnesemia, Primary, Due To Defect In Renal Tubular Transport Of Magnesium	Hypomagnesemia, Isolated Renal
Hypomagnesemia, Familial, With Hypercalciuria And Nephrocalcinosis	Familial Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement
Isolated Renal Hypomagnesemia	Primary Hypomagnesemia Due To Defect In Renal Tubular Transport Of Magnesium
Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement	Hypomagnesemia 3
Familial Hypomagnesemia With Hypercalciuria And Nephrocalcinosis	Fhhnc
Hhn	Renal Hypomagnesemia Hypercalciuria Nephrocalcinosis
Hypomagnesemia, Type 3, Renal	Primary Hypomagnesemia

Progesterone-Receptor Positive Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12084	RNF25 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNF25	VGNC	VGNC:76736
Bos taurus	RNF25	VGNC	VGNC:34060
Rattus norvegicus	RNF25	RGD	RGD:1311557
Felis catus	RNF25	VGNC	VGNC:64698
Mus musculus	RNF25	MGD	MGI:1890215
Canis familiaris	RNF25	VGNC	VGNC:45665

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