SLC3A2 - solute carrier family 3 member 2 Gene

Homo sapiens

Also known as 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC

Gene ID: 6520 | Gene type: protein coding

About SLC3A2

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,856,109-62,888,860 (from NCBI)

This gene has 41 transcripts (splice variants), 275 orthologues and 7 paralogues. Ubiquitous expression in kidney (RPKM 68.6), bone marrow (RPKM 41.5) and 25 other tissues.

Summary

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible LIGHT chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type Amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

SLC3A2 Products(4)

mRNA	Protein	Name
NM_001012662.3	NP_001012680.1	4F2 cell-surface antigen heavy chain isoform b
NM_001012664.3	NP_001012682.1	4F2 cell-surface antigen heavy chain isoform e
NM_001013251.3	NP_001013269.1	4F2 cell-surface antigen heavy chain isoform f
NM_002394.6	NP_002385.3	4F2 cell-surface antigen heavy chain isoform c

SLC3A2 Protein Structure

Alpha-amylase

0
100
200
300
400
500
630 a.a.

Protein Preferred Names

Protein Names

4F2 cell-surface antigen heavy chain

CD98 heavy chain

Recombinant SLC3A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75368	CD98 Protein, Human (HEK293, His)	P08195-1 (R206-A630)	≥95%

Related Diseases

Diseases

Alias

Lysinuric Protein Intolerance

LPI	Dibasic Amino Aciduria Ii
Hyperdibasic Aminoaciduria	Dibasic Aminoaciduria 2
Dibasicamino Aciduria Ii	Congenital Lysinuria
Lpi - Lysinuric Protein Intolerance

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Choriocarcinoma

Chorioepithelioma

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Null-Cell Leukemia

Null Cell Acute Lymphoblastic Leukemia	Null Cell Acute Lymphoblastic Leukaemia
Null-Cell Leukaemia

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon	Stage 0 Colonic Carcinoma
Stage 0 Carcinoma Of Colon	Intraepithelial Neoplasia Of Colon, High Grade
Carcinoma In Situ Of Cecum	Carcinoma In Situ Of Hepatic Flexure
Carcinoma In Situ Of Ileocecal Valve	Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ

Lung Pleomorphic Carcinoma

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Akinetopsia

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13242	SLC3A2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC3A2	RGD	RGD:3073
Mus musculus	SLC3A2	MGD	MGI:96955
Macaca mulatta	SLC3A2	VGNC	VGNC:77463
Bos taurus	SLC3A2	VGNC	VGNC:34871
Canis familiaris	SLC3A2	VGNC	VGNC:46410
Felis catus	SLC3A2	VGNC	VGNC:65366
Others	SLC3A2	NCBI

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