SPAM1 - sperm adhesion molecule 1 Gene

Homo sapiens

Also known as HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n

Gene ID: 6677 | Gene type: protein coding

About SPAM1

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,925,241-123,971,414 (from NCBI)

This gene has 7 transcripts (splice variants), 239 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 5.9).

Summary

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored Enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

SPAM1 Products(5)

mRNA	Protein	Name
NM_001174044.2	NP_001167515.1	hyaluronidase PH-20 isoform 2
NM_001174045.2	NP_001167516.1	hyaluronidase PH-20 isoform 2
NM_001174046.2	NP_001167517.1	hyaluronidase PH-20 isoform 2
NM_003117.5	NP_003108.2	hyaluronidase PH-20 isoform 1
NM_153189.3	NP_694859.1	hyaluronidase PH-20 isoform 2

SPAM1 Protein Structure

Glyco_hydro_56

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

hyaluronidase PH-20

PH-20 hyaluronidase

Recombinant SPAM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78780	PH20/SPAM1 Protein, Human (HEK293, His)	P38567 (L36-Y482)	≥95%

Related Diseases

Diseases

Alias

Mucopolysaccharidosis, Type Ix

Mucopolysaccharidosis Type Ix	Hyaluronidase Deficiency
MPS9	Mps Ix
Mucopolysaccharidosis Ix	Mpsix
Mucopolysaccharidosis Type 9	Mucopolysaccharidosis 9

Idiopathic Corneal Edema

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Mucopolysaccharidosis, Type Ivb

Mucopolysaccharidosis Type Ivb	Mps Ivb
MPS4B	Morquio Syndrome B
Beta-D-Galactosidase Deficiency	Morquio Disease Type B
Mps 4b	Mucopolysaccharidosis Type 4b
Mpsivb	Morquio Disease, Type B
Mucopolysaccharidosis Type Iv-B	Mucopolysaccharidosis 4b
Morquio'S Syndrome B	Mps-Ivb

Mucopolysaccharidosis, Type Iiid

Mucopolysaccharidosis Type Iiid	MPS3D
Mps Iiid	N-Acetylglucosamine-6-Sulfatase Deficiency
Sanfilippo Syndrome D	Gns Deficiency
Mucopolysaccharidosis Type 3d	Sanfilippo Syndrome Type D
Glucosamine N-Acetyl-6-Sulfatase Deficiency	Mpsiiid
Mps 3d	Mucopoly-Saccharidosis Type 3d
N-Acetylglucosamine-6-Sulfate Sulfatase Deficiency	Mps Iii-D
Mucopolysaccharidosis 3d	Sanfilippo D Syndrome
Mps Iii D

Mucopolysaccharidosis-Plus Syndrome

Mucopolysaccharidosis	Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
MPSPS	Mucopolysaccharidoses
Mps	Mucopolysaccharidosis-Like Plus Disease
Disorders Of Glycosaminoglycan Metabolism

Mucopolysaccharidosis, Type Iva

Mps Iva	Galns Deficiency
MPS4A	Morquio A Disease
Galactosamine-6-Sulfatase Deficiency	Morquio Syndrome A
Mucopolysaccharidosis Iva	Mucopolysaccharidosis Type Iva
Mpsiva	Morquio Disease Type A
Mucopolysaccharidosis Type 4a	N-Acetylgalactosamine-6-Sulfate Sulfatase Deficiency
Morquio Syndrome Type A	Mps 4a
Morquio Disease, Type A	Mucopolysaccharidosis 4a
Morquio'S Syndrome A	Mps Iv A
Mucopolysaccharidosis Iv	Mucopolysaccharidosis, Mps-Iv-A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13628	SPAM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SPAM1	VGNC	VGNC:77853
Canis familiaris	SPAM1	VGNC	VGNC:46700
Rattus norvegicus	SPAM1	RGD	RGD:620547
Felis catus	SPAM1	VGNC	VGNC:65600

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