SSR2 - signal sequence receptor subunit 2 Gene

Homo sapiens

Also known as TLAP; HSD25; TRAPB; TRAP-BETA

Gene ID: 6746 | Gene type: protein coding

About SSR2

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,009,048-156,020,951 (from NCBI)

This gene has 18 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in ovary (RPKM 141.0), adrenal (RPKM 105.9) and 25 other tissues.

Summary

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

SSR2 Products(1)

mRNA	Protein	Name
NM_003145.4	NP_003136.1	translocon-associated protein subunit beta precursor

SSR2 Protein Structure

TRAP_beta

0
100
183 a.a.

Protein Preferred Names

Protein Names

translocon-associated protein subunit beta

SSR-beta

Related Diseases

Diseases

Alias

Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Synostoses, Tarsal, Carpal, And Digital

Calcaneonavicular Coalition	Multiple Synostosis Syndrome
Synostoses, Tarsal, Carpal And Digital

Ectopic Cushing Syndrome

Cushing Syndrome Due To Ectopic Acth Secretion	Ectopic Acth Secreting Tumor
Adrenocorticotropic Hormone Secretion Syndrome	Occult Ectopic Acth Secretion
Paraneoplastic Cushing Syndrome

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Tylosis With Esophageal Cancer

Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome	TOC
Keratosis Palmaris Et Plantaris With Esophageal Cancer	Bennion-Patterson Syndrome
Howell-Evans Syndrome	Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome
Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome	Tylosis-Oesophageal Carcinoma Syndrome
Palmoplantar Keratoderma With Esophageal Cancer	Howel-Evans Syndrome
Keratosis Palmoplantaris With Esophageal Cancer	Tylosis - Oesophageal Carcinoma
Howel-Evans' Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13815	SSR2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSR2	VGNC	VGNC:46838
Felis catus	SSR2	VGNC	VGNC:107945
Mus musculus	SSR2	MGD	MGI:1913506
Bos taurus	SSR2	VGNC	VGNC:35320
Macaca mulatta	SSR2	VGNC	VGNC:77889
Rattus norvegicus	SSR2	RGD	RGD:1308365