SS18 - SS18 subunit of BAF chromatin remodeling complex Gene

Homo sapiens

Also known as SYT; SSXT; SMARCL1

Gene ID: 6760 | Gene type: protein coding

About SS18

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:26,016,253-26,091,219 (from NCBI)

This gene has 26 transcripts (splice variants), 212 orthologues, 2 paralogues and is associated with 73 phenotypes. Ubiquitous expression in thyroid (RPKM 26.0), adrenal (RPKM 22.3) and 25 other tissues.

Summary

Enables nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of SWI/SNF complex. Implicated in synovial sarcoma. [provided by Alliance of Genome Resources, Apr 2022]

SS18 Products(3)

mRNA	Protein	Name
NM_001007559.3	NP_001007560.1	protein SSXT isoform 1
NM_001308201.2	NP_001295130.1	protein SSXT isoform 3
NM_005637.4	NP_005628.2	protein SSXT isoform 2

SS18 Protein Structure

SSXT

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

protein SSXT

SS18, nBAF chromatin remodeling complex subunit

Related Diseases

Diseases

Alias

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Colorado Tick Fever

Mountain Tick Fever	Tick Fever, American Mountain
American Mountain Fever	Colorado Tick Encephalitis
Colorado Tick-Borne Disease	Mountain Fever
American Mountain Tick Fever	Colorado Tick-Borne Fever
Colorado Tick Fever Virus	Non-Exanthematous Tick Fever

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Spindle Cell Synovial Sarcoma

Synovial Sarcoma With Spindle Cell Components	Synovial Sarcoma, Monophasic Fibrous
Synovial Sarcoma, Spindle Cell

Kidney Hemangiopericytoma

Hemangiopericytoma Of Kidney

Renal Hemangiopericytoma

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Epithelioid Malignant Peripheral Nerve Sheath Tumor

Epithelioid Mpnst

Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath

Heart Sarcoma

Cardiac Sarcoma

Sarcoma Of Heart

Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Pericardium Cancer

Malignant Neoplasm Of Pericardium	Malignant Tumor Of Pericardium
Pericardial Tumor	Neoplasm Of Pericardium

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Cellular Schwannoma

Cellular Neurinoma

Lung Sarcoma

Pulmonary Sarcoma

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Spindle Cell Thymoma

Medullary Thymoma	Thymoma, Medullary
Thymoma, Type A

Pleomorphic Liposarcoma

Pls	Liposarcoma Pleomorphic
Liposarcoma, Pleomorphic

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Conventional Leiomyosarcoma

Kidney Sarcoma

Renal Sarcoma

Sarcoma Of Kidney

Cellular Myxoid Liposarcoma

Round Cell Liposarcoma

Clear Cell Sarcoma

Sarcoma, Clear Cell	Adult Soft Part Clear Cell Sarcoma
Clear Cell Sarcoma Of Soft Parts	Malignant Melanoma Of Soft Parts
Malignant Melanoma Of Soft Tissues	Melanoma, Malignant, Of Soft Parts
Sarcoma Clear Cell

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Heart Cancer

Malignant Neoplasm Of Heart	Heart Neoplasm
Cardiac Tumor	Malignant Cardiac Tumor
Tumour Of Heart	Heart Neoplasms
Cardiac Carcinoma

Desmoplastic Small Round Cell Tumor

Dsrct	Desmoplastic Small Round-Cell Tumor
Desmoplastic Small Round-Cell Neoplasm

Spindle Cell Rhabdomyosarcoma

Malignant Triton Tumor

Malignant Peripheral Nerve Sheath Neoplasm With Rhabdomyosarcoma	Malignant Triton Tumour
Mpnst With Rhabdomyoblastic Differentiation	Mpnst With Rhabdomyosarcoma
Mpnst With Rhabdomyosarcomatous Differentiation	Mtt
Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differenciation	Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation

Epithelioid Sarcoma

Epithelioid Cell Sarcoma	Sarcoma Epithelioid
Sarcoma, Epithelioid

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Rhabdoid Cancer

Rhabdoid Tumor	Malignant Rhabdoid Tumor
Malignant Rhabdoid Tumour	Rhabdoid Sarcoma
Rhabdoid Tumor Predisposition Syndrome 1	Rhabdoid Tumor Predisposition Syndrome 2
Atypical Teratoid Rhabdoid Tumor	Brain Tumor, Posterior Fossa, Of Infancy, Familial
Atypical Teratoid/Rhabdoid Tumor

Meninges Sarcoma

Meningeal Sarcoma	Sarcoma Of Meninges
Meningothelial Sarcoma	Leptomeningeal Sarcoma

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Muscle Cancer

Myosarcoma	Malignant Neoplasm Of Muscle
Malignant Tumor Of Muscle	Malignant Tumor Of The Muscle
Muscle Neoplasms	Myomatous Neoplasm

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Kidney Cortex Disease

Pseudosarcomatous Fibromatosis

Nodular Fasciitis	Pseudosarcomatous Fasciitis
Fasciitis - Nodular	Fasciitis Nodular

Congenital Fibrosarcoma

Infantile Fibrosarcoma

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal	Rhabdomyosarcoma Embryonal
Botryoid Rhabdomyosarcoma	Erms
Spindle Cell Rhabdomyosarcomas

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13802	SS18 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13803	SS18L2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SS18	VGNC	VGNC:65698
Bos taurus	SS18	VGNC	VGNC:35305
Rattus norvegicus	SS18	RGD	RGD:1311919
Mus musculus	SS18	MGD	MGI:107708
Canis familiaris	SS18	VGNC	VGNC:46823
Macaca mulatta	SS18	VGNC	VGNC:77896
Others	SS18	NCBI