TLE3 - TLE family member 3, transcriptional corepressor Gene

Homo sapiens

Also known as ESG; ESG3; GRG3; HsT18976

Gene ID: 7090 | Gene type: protein coding

About TLE3

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:70,047,790-70,097,917 (from NCBI)

This gene has 24 transcripts (splice variants), 271 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

TLE3 Products(7)

mRNA	Protein	Name
NM_001105192.3	NP_001098662.1	transducin-like enhancer protein 3 isoform b
NM_001282979.2	NP_001269908.1	transducin-like enhancer protein 3 isoform e
NM_001282980.2	NP_001269909.1	transducin-like enhancer protein 3 isoform d
NM_001282981.2	NP_001269910.1	transducin-like enhancer protein 3 isoform f
NM_001282982.2	NP_001269911.1	transducin-like enhancer protein 3 isoform g
NM_005078.4	NP_005069.2	transducin-like enhancer protein 3 isoform a
NM_020908.3	NP_065959.1	transducin-like enhancer protein 3 isoform c

TLE3 Protein Structure

TLE_N

WD40

0
200
400
600
772 a.a.

Protein Preferred Names

Protein Names

transducin-like enhancer protein 3

enhancer of split groucho 3

Recombinant TLE3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76675	TLE3 Protein, Human (GST)	Q04726 (S484-Y772)	≥95%

Related Diseases

Diseases

Alias

Chromosome 1q21.1 Duplication Syndrome

1q21.1 Microduplication Syndrome	Trisomy 1q21.1
1q21.1 Duplication Syndrome	1q21.1 Microduplication
1q21.1 Duplication	Dup(1)(Q21.1)

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14565	TLE3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TLE3	MGD	MGI:104634
Rattus norvegicus	TLE3	RGD	RGD:620292
Macaca mulatta	TLE3	VGNC	VGNC:78366
Felis catus	TLE3	VGNC	VGNC:66210
Canis familiaris	TLE3	VGNC	VGNC:47397
Bos taurus	TLE3	VGNC	VGNC:35891
Others	TLE3	NCBI