TUB - TUB bipartite transcription factor Gene

Homo sapiens

Also known as rd5; RDOB

Gene ID: 7275 | Gene type: protein coding

About TUB

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,019,059-8,106,243 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 18.8), endometrium (RPKM 10.0) and 21 other tissues.

Summary

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

TUB Products(2)

mRNA	Protein	Name
NM_003320.5	NP_003311.2	tubby protein homolog isoform a
NM_177972.3	NP_813977.1	tubby protein homolog isoform b

TUB Protein Structure

Tub

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

tubby protein homolog

tubby bipartite transcription factor

Recombinant TUB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P701073	Tubby Protein, Human (His)	P50607-1 (M1-E506)	≥95%

Related Diseases

Diseases

Alias

Retinal Dystrophy And Obesity

RDOB	Dystrophy, Retinal, And Obesity

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Coffin-Siris Syndrome 2

CSS2	Mrd14
Mental Retardation, Autosomal Dominant 14	Autosomal Dominant Mental Retardation 14
Coffin-Siris Syndrome, Type 2

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Multidrug-Resistant Tuberculosis

Tuberculosis, Multidrug-Resistant

Tuberculosis Multidrug-Resistant

Bagassosis

Sugar Cane Worker Pneumonitis	Bagasse Workers' Lung
Bagasse Disease	Bagasse Disease Or Pneumonitis
Bagasse Workers' Disease	Fibrosis Of Lung With Bagassosis
Sugar Cane Workers' Hypersensitivity Pneumonitis	Bagasse Pneumonitis
Hypersensitivity Pneumonitis With Bagassosis

Tinea Nigra

Microsporosis Nigra	Infection By Cladosporium Werneckii
Keratomycosis Nigricans	Tinea Palmaris Nigra
Keratomycosis Nigricans Palmaris

Night Blindness

Nyctalopia

Cardiomyopathy, Familial Hypertrophic, 16

Hypertrophic Cardiomyopathy 16	CMH16
Cardiomyopathy, Hypertrophic, 16	Cardiomyopathy Familial Hypertrophic 16
Cardiomyopathy, Familial Hypertrophic 16	Cardiomyopathy, Hypertrophic, Familial, Type 16

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Cardiomyopathy, Familial Hypertrophic, 18

Hypertrophic Cardiomyopathy 18	CMH18
Cardiomyopathy, Hypertrophic, 18	Cardiomyopathy Familial Hypertrophic 18
Cardiomyopathy, Familial Hypertrophic 18	Cardiomyopathy, Hypertrophic, Familial, Type 18

Lip Cancer

Malignant Neoplasm Of Lip	Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Tumour Of Lip	Lip Neoplasms
Malignant Neoplasm Of Commissure Of Lip	Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower
Malignant Neoplasm Of Labial Commissure Of Lip	Malignant Neoplasm Of Lip, External
Malignant Neoplasm Of Lip, Inner Aspect	Malignant Neoplasm Of Lip, Vermilion Border
Malignant Neoplasm Of Lower Lip, Buccal Aspect	Malignant Neoplasm Of Lower Lip, Inner Aspect
Malignant Neoplasm Of Lower Lip, Mucosa	Malignant Neoplasm Of Lower Lip, Oral Aspect
Malignant Neoplasm Of Other Sites Of Lip	Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Tumor Of Commissure Of Lip	Malignant Tumor Of Labial Mucosa
Malignant Tumor Of Lip	Malignant Tumor Of Lower Labial Mucosa
Malignant Tumor Of The Lip	Malignant Tumour Of Labial Commissure
Cancer Of Lip	Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip
Upper Lip Cancer	Lower Lip Cancer
Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip	Primary Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Neoplasm Of Lipstick Area Of Upper Lip	Malignant Neoplasm Of Upper Lip Nos
Malignant Neoplasm Of Vermilion Border Of Upper Lip	Malignant Neoplasm Of Lipstick Area Of Lower Lip
Malignant Neoplasm Of Lower Lip Nos	Malignant Neoplasm Of Vermilion Border Of Lower Lip
Malignant Neoplasm Of Vermilion Border Nos	Malignant Neoplasm Of Buccal Aspect Of Upper Lip
Malignant Neoplasm Of Frenulum Of Upper Lip	Malignant Neoplasm Of Mucosa Of Upper Lip
Malignant Neoplasm Of Oral Aspect Of Upper Lip	Malignant Neoplasm Of Buccal Aspect Of Lower Lip
Malignant Neoplasm Of Frenulum Of Lower Lip	Malignant Neoplasm Of Mucosa Of Lower Lip
Malignant Neoplasm Of Oral Aspect Of Lower Lip	Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower	Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower
Primary Malignant Neoplasm Of Commissure Of Lip	Primary Malignant Neoplasm Of Lip
Malignant Neoplasm Of Lip, Unspecified

Bird Fancier'S Lung

Bird Fancier Lung	Pigeon Breeder'S Lung
Avian Hypersensitivity Pneumonitis	Bird Breeder'S Lung
Bird-Fancier'S Lung	Bird-Fanciers' Lung
Poultry Worker'S Lung	Pigeon-Breeder Lung Disease
Pigeon Breeders Lung	Avian Protein Hypersensitivity
Bird Breeders' Disease	Bird Breeders' Lung
Bird Fanciers' Lung	Bird Fanciers' Disease
Bfl - [Bird Fancier Lung]	Fanciers' Disease
Fanciers' Lung

Cardiomyopathy, Familial Hypertrophic, 17

Hypertrophic Cardiomyopathy 17	CMH17
Cardiomyopathy, Hypertrophic, 17	Cardiomyopathy Familial Hypertrophic 17
Cardiomyopathy, Familial Hypertrophic 17	Cardiomyopathy, Hypertrophic, Familial, Type 17

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13250	Silvestrol aglycone	Inhibitor	99.70%	Unkown
HY-148450	eIF4A3-IN-16	Inhibitor	98.37%	Unkown
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	Unkown
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	Unkown
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	Unkown
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	Unkown
HY-148447	eIF4A3-IN-13	Inhibitor	99.92%	Unkown
HY-148449	eIF4A3-IN-15	Inhibitor	/	Unkown
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	Unkown
HY-RS15244	TUB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TUB	VGNC	VGNC:78672
Bos taurus	TUB	VGNC	VGNC:36503
Mus musculus	TUB	MGD	MGI:2651573
Rattus norvegicus	TUB	RGD	RGD:3918
Felis catus	TUB	VGNC	VGNC:66696
Canis familiaris	TUB	VGNC	VGNC:47986
Others	TUB	NCBI

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