2. Gene
  3. UBE2G2 - ubiquitin conjugating enzyme E2 G2 Gene

UBE2G2 - ubiquitin conjugating enzyme E2 G2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UBC7

Gene ID: 7327 | Gene type: protein coding

About UBE2G2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,768,580-44,801,820 (from NCBI)

This gene has 12 transcripts (splice variants), 197 orthologues and 24 paralogues. Ubiquitous expression in spleen (RPKM 19.6), appendix (RPKM 19.0) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2G2 Products(3)

mRNA Protein Name
NM_001202489.2 NP_001189418.1 ubiquitin-conjugating enzyme E2 G2 isoform 3
NM_003343.6 NP_003334.2 ubiquitin-conjugating enzyme E2 G2 isoform 1
NM_182688.3 NP_872630.1 ubiquitin-conjugating enzyme E2 G2 isoform 2

UBE2G2 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 157)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 G2

E2 ubiquitin-conjugating enzyme G2

Recombinant UBE2G2 Proteins

Cat. No. Product Name Accession Purity
HY-P71401 UBE2G2 Protein, Human (GST) P60604 (M1-L165) ≥95%

Related Diseases

Diseases Alias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15347 UBE2G2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBE2G2 VGNC VGNC:36582
Rattus norvegicus UBE2G2 RGD RGD:1304860
Canis familiaris UBE2G2 VGNC VGNC:48053
Mus musculus UBE2G2 MGD MGI:1343188
Others UBE2G2 NCBI