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  3. Nuak2 - NUAK family, SNF1-like kinase, 2 Gene

Nuak2 - NUAK family, SNF1-like kinase, 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Snark; Omphk2; mKIAA0537; 1200013B22Rik

Gene ID: 74137 | Gene type: protein coding

About Nuak2

Chromosome 1: 132,243,864-132,261,226 forward strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 213 orthologues, 19 paralogues and is associated with 8 phenotypes. Broad expression in large intestine adult (RPKM 25.5), small intestine adult (RPKM 23.1) and 19 other tissues.

Summary

Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of apoptotic process; and protein phosphorylation. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be active in cytoplasm. Is expressed in several structures, including lung; neural ectoderm; nose; paravertebral ganglion; and ventricular layer. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nuak2 Products(2)

mRNA Protein Name
NM_001195025.1 NP_001181954.1 NUAK family SNF1-like kinase 2 isoform A
NM_028778.4 NP_083054.1 NUAK family SNF1-like kinase 2 isoform B

Nuak2 Protein Structure

STKc_NUAK2

STKc_NUAK2: cd14161 (52 - 306)

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  • 631 a.a.
Protein Preferred Names Protein Names

NUAK family SNF1-like kinase 2

SNF1MP-activated protein kinase

omphalocele kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15802 WZ4003 Inhibitor 98.88% Unkown
HY-120877 MRT199665 Inhibitor 99.92% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nuak2 NCBI NCBI:81788