FMNL1 - formin like 1 Gene

Homo sapiens

Also known as FMNL; FHOD4; KW-13; C17orf1; C17orf1B

Gene ID: 752 | Gene type: protein coding

About FMNL1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,221,885-45,247,318 (from NCBI)

This gene has 11 transcripts (splice variants), 287 orthologues and 18 paralogues. Biased expression in bone marrow (RPKM 59.8), appendix (RPKM 26.8) and 11 other tissues.

Summary

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

FMNL1 Products(2)

mRNA	Protein	Name
NM_001411128.1	NP_001398057.1	formin-like protein 1 isoform 2
NM_005892.4	NP_005883.3	formin-like protein 1 isoform 1

FMNL1 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1000
1100 a.a.

Protein Preferred Names

Protein Names

formin-like protein 1

CLL-associated antigen KW-13

Related Diseases

Diseases

Alias

Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish	Fdd
Familial Danish Dementia	Heredopathia Ophthalmootoencephalica
Hooe	Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis
Adan Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy 2
Itm2b Amyloidosis	Familial Cerebral Amyloid Angiopathy
Itm2b-Related Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy
Familial Dementia, Danish Type	Cerebral Amyloid Angiopathy, Itm2b-Related 2
CAA-ITM2B2	Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis
Dementia, Familial, Danish

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05002	FMNL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FMNL1	VGNC	VGNC:40914
Felis catus	FMNL1	VGNC	VGNC:62304
Macaca mulatta	FMNL1	VGNC	VGNC:72480
Rattus norvegicus	FMNL1	RGD	RGD:1311042
Mus musculus	FMNL1	MGD	MGI:1888994
Bos taurus	FMNL1	VGNC	VGNC:29046

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