GLRA3 - glycine receptor alpha 3 Gene

Homo sapiens

Gene ID: 8001 | Gene type: protein coding

About GLRA3

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:174,636,920-174,829,247 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 45 paralogues. Biased expression in brain (RPKM 2.6), adrenal (RPKM 0.4) and 1 other tissue.

Summary

This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GLRA3 Products(2)

mRNA	Protein	Name
NM_001042543.3	NP_001036008.1	glycine receptor subunit alpha-3 isoform b precursor
NM_006529.4	NP_006520.2	glycine receptor subunit alpha-3 isoform a precursor

GLRA3 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

glycine receptor subunit alpha-3

glycine receptor, alpha-3 polypeptide

Related Diseases

Diseases

Alias

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05494	GLRA3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GLRA3	RGD	RGD:621229
Canis familiaris	GLRA3	VGNC	VGNC:41270
Mus musculus	GLRA3	MGD	MGI:95749
Felis catus	GLRA3	VGNC	VGNC:62590
Macaca mulatta	GLRA3	VGNC	VGNC:73076
Bos taurus	GLRA3	VGNC	VGNC:56969

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