2. Gene
  3. SCN1A - sodium voltage-gated channel alpha subunit 1 Gene

SCN1A - sodium voltage-gated channel alpha subunit 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81574 | Gene type: protein coding

About SCN1A

Primary_assembly 3: 50,952,791-51,071,699 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 140 orthologues, 26 paralogues and is associated with 55 phenotypes. Biased expression in Brain (RPKM 38.6), Heart (RPKM 37.9) and 1 other tissue.

Summary

Enables sodium ion binding activity and voltage-gated Sodium Channel activity. Involved in neuronal action potential. Located in plasma membrane. Part of voltage-gated Sodium Channel complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Dravet syndrome; developmental and epileptic encephalopathy; familial hemiplegic migraine 3; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Orthologous to human SCN1A (sodium voltage-gated channel alpha subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

SCN1A Products(1)

mRNA Protein Name
NM_030875.2 NP_110502.2 sodium channel protein type 1 subunit alpha

SCN1A Protein Structure

Ion_trans

Ion_trans: pfam00520 (126 - 432)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (554 - 717)

Ion_trans

Ion_trans: pfam00520 (766 - 979)

Na_trans_assoc

Na_trans_assoc: pfam06512 (1005 - 1212)

Ion_trans

Ion_trans: pfam00520 (1216 - 1491)

Na_channel_gate

Na_channel_gate: cd13433 (1483 - 1535)

Ion_trans

Ion_trans: pfam00520 (1539 - 1795)

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  • 2009 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 1 subunit alpha

sodium channel protein type 1 subunit alpha-like

sodium channel protein type I subunit alpha

sodium channel protein, brain I subunit alpha

sodium channel, voltage-gated, type 1, alpha polypeptide

sodium channel, voltage-gated, type I, alpha polypeptide

sodium channel, voltage-gated, type I, alpha subunit

voltage-gated sodium channel subunit alpha Nav1.1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148410 Zorevunersen Activator / Unkown
HY-148410A Zorevunersen sodium Inhibitor / Unkown
HY-RS12525 SCN1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12526 Scn1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12527 SCN1A Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SCN1A NCBI NCBI:6323