2. Gene
  3. Mchr1 - melanin-concentrating hormone receptor 1 Gene

Mchr1 - melanin-concentrating hormone receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Slc1; Gpr24; Mch-1r

Gene ID: 83567 | Gene type: protein coding

About Mchr1

Primary_assembly 7: 112,761,554-112,764,032 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 241 orthologues, 50 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 31.9), Muscle (RPKM 4.3) and 2 other tissues.

Summary

Enables hormone binding activity; melanin-concentrating hormone receptor activity; and protein C-terminus binding activity. Involved in cell surface receptor signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mchr1 Products(1)

mRNA Protein Name
NM_031758.1 NP_113946.1 melanin-concentrating hormone receptor 1

Mchr1 Protein Structure

7tmA_MCHR1

7tmA_MCHR1: cd15338 (40 - 321)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (41 - 67)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (77 - 103)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (115 - 145)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (157 - 177)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (204 - 233)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (248 - 278)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (289 - 314)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

melanin-concentrating hormone receptor 1

G-protein coupled receptor 24

MCH receptor 1

MCH-R1

MCH1R

MCHR

MCHR-1

SLC-1

somatostatin receptor-like protein

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-U00257 AZD1979 Antagonist 98.09% Phase 1
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107625A SNAP 94847 hydrochloride Inhibitor 99.90% Unkown
HY-P1204 [Ala17]-MCH Agonist 98.28% Unkown
HY-100321 MCHR1 antagonist 2 98.27% Unkown
HY-12433 BMS-819881 / Unkown
HY-100318 NGD-4715 Antagonist / Unkown
HY-107625 SNAP 94847 Antagonist / Unkown
HY-120608 BMS-814580 Inhibitor / Unkown
HY-136152 MCHR1 antagonist 3 Antagonist / Unkown
HY-P1204A [Ala17]-MCH TFA Agonist / Unkown
HY-RS08225 MCHR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08226 Mchr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08227 Mchr1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-101699A AMG-076 Antagonist / Unkown
HY-U00353 MCHR1 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mchr1 NCBI NCBI:2847