2. Gene
  3. ULK1 - unc-51 like autophagy activating kinase 1 Gene

ULK1 - unc-51 like autophagy activating kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ATG1; ATG1A; UNC51; hATG1; Unc51.1

Gene ID: 8408 | Gene type: protein coding

About ULK1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,894,622-131,923,150 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues.

Summary

Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

ULK1 Products(4)

mRNA Protein Name
XM_011538799.3 XP_011537101.1 serine/threonine-protein kinase ULK1 isoform X2
XM_011538798.4 XP_011537100.1 serine/threonine-protein kinase ULK1 isoform X1
XR_007063134.1
NM_003565.4 NP_003556.2 serine/threonine-protein kinase ULK1

ULK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (18 - 278)

DUF3543

DUF3543: Domain of unknown function (DUF3543) (833 - 1045)

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  • 200
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  • 800
  • 1050 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK1

ATG1 autophagy related 1 homolog

autophagy-related protein 1 homolog

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Acute Laryngopharyngitis

Pharyngolaryngitis

Laryngopharyngitis

Hypopharyngitis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16966 SBI-0206965 Inhibitor 99.39% Unkown
HY-13018 MRT67307 Inhibitor 99.34% Unkown
HY-114490 ULK-101 Inhibitor 99.96% Unkown
HY-124729 BL-918 Activator 99.98% Unkown
HY-137742 SBP-7455 Inhibitor 98.24% Unkown
HY-148063 DB0614 98.80% Unkown
HY-143466 ULK1-IN-2 Inhibitor 99.09% Unkown
HY-137506 XST-14 Inhibitor 99.69% Unkown
HY-160699 DCC-3116 Inhibitor / Unkown
HY-148061 DB1113 99.28% Unkown
HY-101923A LYN-1604 hydrochloride Activator / Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-101923 LYN-1604 Activator / Unkown
HY-162100 MR-2088 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ULK1 VGNC VGNC:36658
Mus musculus ULK1 MGD MGI:1270126
Canis familiaris ULK1 VGNC VGNC:48128
Macaca mulatta ULK1 VGNC VGNC:78715
Felis catus ULK1 VGNC VGNC:66814
Rattus norvegicus ULK1 RGD RGD:1589743