2. Gene
  3. CUL4A - cullin 4A Gene

CUL4A - cullin 4A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8451 | Gene type: protein coding

About CUL4A

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,208,193-113,267,108 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 20.5), heart (RPKM 17.9) and 25 other tissues.

Summary

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

CUL4A Products(11)

mRNA Protein Name
NM_001008895.4 NP_001008895.1 cullin-4A isoform 1
NM_001278513.3 NP_001265442.1 cullin-4A isoform 2
NM_001278514.3 NP_001265443.1 cullin-4A isoform 3
NM_001354938.2 NP_001341867.1 cullin-4A isoform 2
NM_001354939.2 NP_001341868.1 cullin-4A isoform 2
NM_001354940.2 NP_001341869.1 cullin-4A isoform 2
NM_001354941.2 NP_001341870.1 cullin-4A isoform 4
NM_001354942.2 NP_001341871.1 cullin-4A isoform 4
NM_001354943.2 NP_001341872.1 cullin-4A isoform 5
NM_001354944.2 NP_001341873.1 cullin-4A isoform 6
NM_003589.4 NP_003580.1 cullin-4A isoform 2

CUL4A Protein Structure

Cullin

Cullin: Cullin family (63 - 661)

Cullin_Nedd8

Cullin_Nedd8: Cullin protein neddylation domain (689 - 753)

  • 0
  • 200
  • 400
  • 600
  • 759 a.a.
Protein Preferred Names Protein Names

cullin-4A

CUL-4A

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V

Xp5

Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

Xpe

Xp, Group E

Xeroderma Pigmentosum, Type 5

Xeroderma Pigmentosum Complementation Group E

XP-E

Xp Group E
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E

Xeroderma Pigmentosum V

Xp Group E

Xp5

Xpe

Xeroderma Pigmentosum, Complementation Group E
Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C

XPC

Xpcc

Xeroderma Pigmentosum Iii

Xp3

Xeroderma Pigmentosum Group C

Xp Group C

Xp, Group C

Xeroderma Pigmentosum, Type 3

Xeroderma Pigmentosum Complementation Group C

XP-C
Childhood Medulloblastoma

Medulloblastoma, Childhood

Pediatric Medulloblastoma

Medulloblastoma Childhood
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1
De Sanctis-Cacchione Syndrome

Xerodermic Idiocy

Xeroderma Pigmentosum With Neurologic Manifestation

DSC

Xerodermic Idiocy Of De Sanctis And Cacchione
Uv-Sensitive Syndrome

Uvss

Uv Sensitive Syndrome

Ultraviolet Sensitive Syndrome
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
Three M Syndrome 1

3-M Syndrome

Yakut Short Stature Syndrome

3m Syndrome

Le Merrer Syndrome

Dolichospondylic Dysplasia

Gloomy Face Syndrome

Three M Syndrome

3M1

3m Syndrome 1

Miller-Mckusick-Malvaux Syndrome

3-Msbn

Three-M Slender-Boned Nanism

Miller-Mckusick-Malvaux-Syndrome

3-M Syndrome 1

3m Syndrome-1

3m Syndrome, Type 1

Dwarfism

Dwarfism Tall Vertebrae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148602 KH-4-43 99.99% Unkown
HY-161166 MM-02-57 / Unkown
HY-RS03362 CUL4A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CUL4A VGNC VGNC:27832
Rattus norvegicus CUL4A RGD RGD:1563853
Mus musculus CUL4A MGD MGI:1914487
Macaca mulatta CUL4A VGNC VGNC:71568
Felis catus CUL4A VGNC VGNC:97394
Canis familiaris CUL4A VGNC VGNC:39731
Others CUL4A NCBI