SUPT3H - SPT3 homolog, SAGA and STAGA complex component Gene

Homo sapiens

Also known as SPT3; SPT3L

Gene ID: 8464 | Gene type: protein coding

About SUPT3H

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,809,057-45,377,934 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.0) and 24 other tissues.

Summary

Enables transcription coactivator activity. Involved in histone H3 acetylation and histone deubiquitination. Located in nucleoplasm. Part of SAGA complex and transcription factor TFTC complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT3H Products(8)

mRNA	Protein	Name
NM_001261823.2	NP_001248752.1	transcription initiation protein SPT3 homolog isoform 3
NM_001350324.2	NP_001337253.1	transcription initiation protein SPT3 homolog isoform 4
NM_001350325.2	NP_001337254.1	transcription initiation protein SPT3 homolog isoform 5
NM_001350326.2	NP_001337255.1	transcription initiation protein SPT3 homolog isoform 6
NM_001350327.2	NP_001337256.1	transcription initiation protein SPT3 homolog isoform 7
NM_001350329.2	NP_001337258.1	transcription initiation protein SPT3 homolog isoform 1
NM_003599.4	NP_003590.1	transcription initiation protein SPT3 homolog isoform 1
NM_181356.3	NP_852001.1	transcription initiation protein SPT3 homolog isoform 2

SUPT3H Protein Structure

TFIID-18kDa

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

transcription initiation protein SPT3 homolog

SPT3-like protein

Related Diseases

Diseases

Alias

Cleidocranial Dysplasia

Cleidocranial Dysostosis	CLCD
Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only	Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly
CCD	Marie-Sainton Disease
Dysplasia Cleidocranial	Dento-Osseous Dysplasia
Marie-Sainton Syndrome	Dysplasia, Cleidocranial

Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic	Familial Hepatic Adenoma
Familial Liver Cell Adenomas	Liver Cell Adenomas, Familial
Hepatic Adenomas Familial	HEPAF
Ha	Hepatocellular Adenomas
Hepatocellular Adenoma

Malignant Giant Cell Tumor Of Soft Parts

Malignant Giant Cell Neoplasm Of Soft Parts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14036	SUPT3H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SUPT3H	VGNC	VGNC:46990
Bos taurus	SUPT3H	VGNC	VGNC:35479
Mus musculus	SUPT3H	MGD	MGI:1923723
Macaca mulatta	SUPT3H	VGNC	VGNC:78055
Felis catus	SUPT3H	VGNC	VGNC:65847
Rattus norvegicus	SUPT3H	RGD	RGD:1591316

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