2. Gene
  3. H2BC12 - H2B clustered histone 12 Gene

H2BC12 - H2B clustered histone 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as H2BK; H2B/S; H2BFT; H2BFAiii; HIST1H2BK

Gene ID: 85236 | Gene type: protein coding

About H2BC12

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,138,293-27,146,858 (from NCBI)

This gene has 1 transcript (splice variant), 164 orthologues and 21 paralogues. Ubiquitous expression in prostate (RPKM 42.3), testis (RPKM 29.8) and 25 other tissues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with Antibacterial and Antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

H2BC12 Products(2)

mRNA Protein Name
NM_001312653.2 NP_001299582.1 histone H2B type 1-K
NM_080593.2 NP_542160.1 histone H2B type 1-K

H2BC12 Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (32 - 101)

  • 0
  • 100
  • 126 a.a.
Protein Preferred Names Protein Names

histone H2B type 1-K

H2B K

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05960 H2BC12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus H2BC12 MGD MGI:2448399
Macaca mulatta H2BC12 VGNC VGNC:109709
Rattus norvegicus H2BC12 RGD RGD:1593016