1. Gene
  2. PDE5A - phosphodiesterase 5A Gene

PDE5A - phosphodiesterase 5A Gene

Homo sapiens

Also known as CN5A; PDE5; CGB-PDE

Gene ID: 8654 | Gene type: protein coding

About PDE5A

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:119,494,403-119,628,804 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues and 20 paralogues. Broad expression in prostate (RPKM 31.5), esophagus (RPKM 20.9) and 20 other tissues.

Summary

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

PDE5A Products(4)

mRNA Protein Name
NM_001083.4 NP_001074.2 cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1
NM_033437.4 NP_246273.2 cGMP-specific 3',5'-cyclic phosphodiesterase isoform 3
NM_033430.3 NP_236914.2 cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2
XM_017008791.3 XP_016864280.1 cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1

PDE5A Protein Structure

GAF

GAF: GAF domain (166 - 312)

GAF

GAF: GAF domain (346 - 503)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (612 - 850)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 875 a.a.
Protein Preferred Names Protein Names

cGMP-specific 3',5'-cyclic phosphodiesterase

cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase

cGMP-specific phosphodiesterase PDE5A2

cGMP-specific phosphodiesterase type 5A

phosphodiesterase 5A, cGMP-specific

phosphodiesterase isozyme 5

Related Diseases

Diseases Alias
Low Compliance Bladder

Overactive Bladder

Hyperactivity Of Bladder

Hypertonic Bladder

Hypertonicity Of Bladder

Low Bladder Compliance

Oab - [Overactive Bladder]

Hypogonadism
Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease

COPD

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Chronic Obstructive Lung Disease

Chronic Obstructive Airway Disease

Pulmonary Disease, Chronic Obstructive, Susceptibility To

Cold

Severe Early-Onset Chronic Obstructive Pulmonary Disease

Pulmonary Disease Chronic Obstructive

Pulmonary Disease, Obstructive, Chronic, Susceptibility To

Chronic Obstructive Pulmonary Disease Of Horses

Common Cold

Upper Respiratory Infections

Copd - [Chronic Obstructive Pulmonary Disease]

Coad - [Chronic Obstructive Airways Disease]

Cold - [Chronic Obstructive Lung Disease]

Chronic Airway Disease Nos

Chronic Airways Limitation, Unspecified

Chronic Obstructed Airway, Unspecified

Chronic Obstructive Airway Disease, Unspecified

Chronic Obstructive Airway, Unspecified

Obstructive Lung Disease Nos

Chronic Obstructive Lung Disease Nos

Chronic Obstructive Lung Nos

Obstructive Pulmonary Disease Nos

Exacerbation Copd Nos

Acute Exacerbation Copd

Hepatic Encephalopathy

Encephalopathy, Hepatic

Portal-Systemic Encephalopathy

Hepatoencephalopathy

He - [Hepatic Encephalopathy]

Hepatic Encephalopathy Nos

Hepatic Encephalopathy, Stage Unspecified

Hepatic Coma

Hepatocerebral Encephalopathy

Hepatocerebral Intoxication

Vasculogenic Impotence

Impotence, Vasculogenic

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Hernia, Congenital Diaphragmatic 1

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

Persistent Fetal Circulation Syndrome

Fetal Circulation

Persistent Fetal Circulation

Persistent Pulmonary Hypertension Of The Newborn

Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

Persistent Foetal Circulation

Persistent Foetal Circulation Syndrome

Pfc - [Persistent Fetal Circulation] Syndrome

Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

Newborn Pulmonary Hypertension

Primary Pulmonary Hypertension Of Newborn

Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease

Obstructive Disease Of The Pulmonary Veins

Pvod

Isolated Pulmonary Venous Sclerosis

Venous Form Of Primary Pulmonary Hypertension

Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Atrial Septal Defect 8

ASD8

Atrial Heart Septal Defect 8

Septal Defect, Atrial, Type 8

Prostatitis
Diastolic Heart Failure

Heart Failure, Diastolic

Chronic Pulmonary Heart Disease
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Priapism

Mentulagra

Priapism, Familial Idiopathic

Familial Idiopathic Priapism

Pathologic Erection

Painful Erection

Peyronie'S Disease

Induratio Penis Plastica

Peyronie Disease

Peyronies Disease

Peyronie'S Fibromatosis

Penile Induration

Balanitis Xerotica Obliterans

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Transient Global Amnesia

Amnesia, Transient Global

Lipid Metabolism Disorder

Dyslipidemia

Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors

Dyslipidemias

Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism

Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect

Tricuspid Valve Disease

Rheumatic Tricuspid Valve Disease

Disease Of Tricuspid Valve

Rh. Tricuspid Valve Disease

Rheumatic Disease Of Tricuspid Valve

Tricuspid Disease

Tricuspid Valve Disorder

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Meconium Aspiration Syndrome

Neonatal Aspiration Of Meconium

Meconium Aspiration

Mas

Meconium Aspiration Syndrome Of Newborn

Meconium Inhalation

Mas - [Meconium Aspiration Syndrome]

Meconium Aspiration Nos

Meconium Aspiration Syndrome Nos

Meconium Pneumonitis

Meconium Stained Liqueur Aspiration

Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy

Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To

NAION

Non-Arteritic Anterior Ischemic Optic Neuropathy

Ischemic Optic Neuropathy

Aion

Optic Neuropathy, Ischemic

Naion, Susceptibility To

Optic Neuropathy, Anterior Ischemic

Optic Neuropathy, Anterior Ischemic, Susceptibility To

Non-Arteritic Anterior Ischaemic Optic Neuropathy

Nonarteritic Anterior Ischaemic Optic Neuropathy

Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To

Ion - [Ischemic Optic Neuropathy]

Neuropathic Ischaemia Of N.Opticus

Ischaemic Neuropathy Of Optic Nerve

Inhibited Female Orgasm

Female Orgasmic Disorder

Articulation Disorder

Phonological Disorder

Articulation Disorders

Articulation Impairment

Speech Sound Disorders

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Cardiovascular Disease

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Urethral Syndrome

Urethral Disease

Urethral Diseases

Urethra Disease

Abnormality Of The Urethra

Urethral Disorders

Speech Disorder

Speech Disorders

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice

Urinary Bladder Neck Obstruction

Bladder Outlet Obstruction

Vesicourethral Orifice Obstruction

Bno - [Bladder Neck Obstruction]

Bladder Obstruction Nos

Acquired Bladder Neck Obstruction

Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice

Bladder Neck Strangulation

Bladder Neck Stricture

Bladder Outflow Obstruction

Contracture Of Bladder Neck Or Sphincter

Contracture Of Bladder Neck

Obstructed Vesicourethral Orifice

Strangulation Of Vesicourethral Orifice

Stricture Of Vesicourethral Orifice

Urinary Prostatic Valve Obstruction

Vesical Obstruction

Stuttering

Stammering

Familial Persistent Stuttering

Stuttering, Familial Persistent 1

Peyronie Disease
Psychosexual Disorder

Psychosexual Disorders

Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm

Sexual Sadism

Sadism

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Ischemia

Acute Coronary Syndrome

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Pure Autonomic Failure

Orthostatic Hypotension

Idiopathic Orthostatic Hypotension

Postural Hypotension

Bradbury-Eggleston Syndrome

Bradbury Eggleston Syndrome

Hypotension, Orthostatic

Hypotension, Postural

Paf

Pure Dysautonomia

Pure Idiopatic Dysautonomia

Hypotension Orthostatic

Primary Orthostatic Hypotension

Chronic Orthostatic Hypotension

Ureterolithiasis

Calculus Of Ureter

Ureteric Stone

Ureteral Calculi

Ureteric Calculus

Stone In The Ureter

Ureter Calculi

Ureteral Calculus Or Stone

Ureterolith

Ureterolithiasis Nos

Optic Nerve Disease

Optic Neuropathy

Disorder Of The Second Nerve

Optic Nerve Disorder

Optic Nerve

Abnormality Of The Optic Nerve

Optic Nerve Disorders

Neuropathy, Optic

Disorder Of The Optic Nerve

Diabetes Mellitus

Diabetes

Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia

BPH

Prostatic Hyperplasia

Premature Ejaculation
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Retinitis Pigmentosa 46

RP46

Retinitis Pigmentosa, Autosomal Recessive, Idh3b-Related

Retinitis Pigmentosa Autosomal Recessive Idh3b-Related

Retinitis Pigmentosa, Type 46

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus

PDA1

Pda

Ductus Arteriosus, Patent

Patent Ductus Arteriosus, Susceptibility To

Patent Ductus Botalli

Patency Of The Ductus Arteriosus

Patent Ductus Arteriosus Familial

Ductus Arteriosus Patent

Patent Ductus Arteriosus - Persisting Type

Pulmonary Valve Insufficiency

Pulmonary Regurgitation

Pulmonary Incompetence

Pulmonary Incompetence, Non-Rheumatic

Pulmonary Insufficiency Following Trauma And Surgery

Pulmonary Regurg.

Pulmonic Insufficiency

Pulmonic Valve Regurgitation

Pulmonary Valve Incompetence

Pulmonary Valve Incompetency

Pulmonary Valvular Insufficiency

Pulmonary Valvular Regurgitation

Pulmonary Valvular Incompetency

Pulmonary Valve Incompetence Nos

Annular Incompetency Pulmonary Valve

Incompetent Pulmonary Valve

Graham Steell Murmur

Pulmonary Valvular Incompetence

Systolic Heart Failure

Heart Failure, Systolic

Crest Syndrome
Penile Disease

Penile Diseases

Raynaud Disease

Raynaud'S Disease

Raynaud Phenomenon

Raynaud'S Syndrome

Raynaud'S

Cold Fingers, Hereditary

Raynaud'S Phenomenon

Raynaud'S Disease/Phenomenon

Raynauds Syndrome

Raynauds Phenomenon

Secondary Raynaud'S Phenomenon

Raynaud Syndrome

Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Vascular Anomaly

Urethral Stricture

Ankylurethria

Urethral Stenosis

Urethral Contracture

Urethral Obstruction

Meatal Stenosis Nos

Constriction Of Urethra

Contraction Of Urethra

Stricture Of Urinary Meatus

Urethral Obliteration

Urethral Narrowing

Pinpoint Meatus

Pinhole Meatus Nos

Urethral Occlusion

Peripheral Vascular Disease

Peripheral Arterial Disease

Arterial Occlusive Disease

Arterial Occlusive Diseases

Pad

Peripheral Vascular Diseases

Peripheral Occlusive Disease

Peripheral Arterial Diseases

Helicobacter Infections

Phimosis

Tight Foreskin

Tight Frenulum

Congenital Phimosis

Tricuspid Valve Insufficiency

Tricuspid Regurgitation

Tricuspid Valve Regurgitation

Tricuspid Incompetence

Tr - [Tricuspid Regurgitation]

Tricuspid Valve Incompetency

Tricuspid Valve Annular Incompetency

Sexual Health Disorder

Sexual Health

Ocular Hyperemia

Hyperemia Eye

Hyperemia Of Conjunctiva

Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder

Neurogenic Urinary Bladder Disorder

Neuropathic Bladder

Bladder Neurogenic

Urinary Bladder, Neurogenic

Neurogenic Urinary Bladder

Female Stress Incontinence

Female Urinary Stress Incontinence

Stress Incontinence - Female

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Disease, Susceptibility To

Coronary Artery Anomaly

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus PDE5A MGD MGI:2651499
Felis catus PDE5A VGNC VGNC:68760
Rattus norvegicus PDE5A RGD RGD:620995
Bos taurus PDE5A VGNC VGNC:32678
Canis familiaris PDE5A VGNC VGNC:44356
Macaca mulatta PDE5A VGNC VGNC:75918
Others PDE5A NCBI