HYAL2 - hyaluronidase 2 Gene

Homo sapiens

Also known as LUCA2

Gene ID: 8692 | Gene type: protein coding

About HYAL2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,317,808-50,322,745 (from NCBI)

This gene has 10 transcripts (splice variants), 294 orthologues, 4 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 78.9), lung (RPKM 35.1) and 20 other tissues.

Summary

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

HYAL2 Products(2)

mRNA	Protein	Name
NM_003773.5	NP_003764.3	hyaluronidase-2 precursor
NM_033158.5	NP_149348.2	hyaluronidase-2 precursor

HYAL2 Protein Structure

Glyco_hydro_56

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

hyaluronidase-2

PH-20 homolog

Recombinant HYAL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79066	Hyaluronidase 2/HYAL2 Protein, Human (CHO, His)	Q12891 (M21-G447 )	≥95%

Related Diseases

Diseases

Alias

Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Hearing Loss Syndrome

Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Deafness Syndrome

Hyaluronidase 2 Deficiency

Cor Triatriatum

Triatrial Heart

Mucopolysaccharidosis, Type Ix

Mucopolysaccharidosis Type Ix	Hyaluronidase Deficiency
MPS9	Mps Ix
Mucopolysaccharidosis Ix	Mpsix
Mucopolysaccharidosis Type 9	Mucopolysaccharidosis 9

Bronchiolo-Alveolar Adenocarcinoma

Bronchioloalveolar Carcinoma	Bronchioalveolar Lung Carcinoma
Minimally Invasive Lung Adenocarcinoma	Carcinoma Bronchioloalveolar
Adenocarcinoma, Bronchiolo-Alveolar	Bronchioloalveolar Adenocarcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06496	HYAL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HYAL2	RGD	RGD:620321
Bos taurus	HYAL2	VGNC	VGNC:30011
Mus musculus	HYAL2	MGD	MGI:1196334
Canis familiaris	HYAL2	VGNC	VGNC:41843
Felis catus	HYAL2	VGNC	VGNC:67679
Macaca mulatta	HYAL2	VGNC	VGNC:73548

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