SAP30 - Sin3A associated protein 30 Gene

Homo sapiens

Gene ID: 8819 | Gene type: protein coding

About SAP30

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:173,370,954-173,377,532 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 10.9), stomach (RPKM 8.8) and 25 other tissues.

Summary

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

SAP30 Products(1)

mRNA	Protein	Name
NM_003864.4	NP_003855.1	histone deacetylase complex subunit SAP30

SAP30 Protein Structure

zf-SAP30

SAP30_Sin3_bdg

0
100
200
220 a.a.

Protein Preferred Names

Protein Names

histone deacetylase complex subunit SAP30

30 kDa Sin3-associated polypeptide

Related Diseases

Diseases

Alias

Phlebotomus Fever

Pappataci Fever	Sandfly Fever
Sandfly-Borne Phleboviral Disease	Sandfly-Borne Arboviral Fever
Sandfly-Borne Bunyavirus Fever	Three Day Fever
Chitral Fever	Italy Summer Grippe
Italy Summer Grippe Influenza

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Rift Valley Fever

Rfv - [Rift Valley Fever]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12440	SAP30 Human Pre-designed siRNA Set A		/	Unkown
HY-RS12441	SAP30BP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SAP30	VGNC	VGNC:76968
Mus musculus	SAP30	MGD	MGI:1929129
Canis familiaris	SAP30	VGNC	VGNC:45860
Rattus norvegicus	SAP30	RGD	RGD:1595501
Felis catus	SAP30	VGNC	VGNC:64869
Bos taurus	SAP30	VGNC	VGNC:34282

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