KCNK17 - potassium two pore domain channel subfamily K member 17 Gene

Homo sapiens

Also known as TALK2; TASK4; TALK-2; TASK-4; K2p17.1

Gene ID: 89822 | Gene type: protein coding

About KCNK17

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,299,001-39,314,419 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 14 paralogues. Broad expression in lung (RPKM 2.2), stomach (RPKM 1.6) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the family of Potassium Channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

KCNK17 Products(2)

mRNA	Protein	Name
NM_001135111.2	NP_001128583.1	potassium channel subfamily K member 17 isoform 2
NM_031460.4	NP_113648.2	potassium channel subfamily K member 17 isoform 1

KCNK17 Protein Structure

Ion_trans_2

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

potassium channel subfamily K member 17

2P domain potassium channel Talk-2

Related Diseases

Diseases

Alias

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Brain Small Vessel Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07156	KCNK17 Human Pre-designed siRNA Set A		/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.